Lesions of the perirhinal cortex impair sensory preconditioning in rats
Lesions of the perirhinal cortex impair sensory preconditioning in rats
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DOI：
10.1016/s0166-4328(00)00168-6
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发表时间：
2000-07-01
影响因子：
2.7
通讯作者：
Freeman, JH
中科院分区：
文献类型：
--
作者：
Nicholson, DA;Freeman, JH
采用感觉预适应的方法，研究皮层损伤对两个条件性刺激之间的联系形成的影响。大鼠接受双侧大脑皮质电解损毁或对照手术。然后，他们被给予配对或不配对的轻CS和声调CS的演示。然后，所有的大鼠都接受了眨眼条件反射程序，包括配对呈现光线或音调，以及眼眶周围电击无条件刺激(US)。最后，这些大鼠接受了一次测试，其中包括不成对的声调和轻柔的css呈现。对照组建立感觉预适应，而损伤组未建立感觉预适应。这一发现与以下观点是一致的，即在中性刺激(即使在没有强化的情况下)的情况下，虹膜周围皮质参与形成联系。(C)2000 Elsevier Science B.V.保留所有权利。
The effects of lesions of the perirhinal cortex on the development of associations between two conditioned stimuli (CSs) were examined with a sensory preconditioning procedure. Rats were given either bilateral electrolytic lesions of the perirhinal cortex or control surgery. They were then given either paired or unpaired presentations of a light CS and a tone CS. All of the rats were then given eyeblink conditioning procedures that involved paired presentations of either the light or tone and a periorbital shock unconditioned stimulus (US). The rats were finally given a test session that consisted of unpaired presentations of the tone and light CSs. Sensory preconditioning was established in the control group, but not in the lesion group. The findings are consistent with the view that the perirhinal cortex is involved in forming associations between neutral stimuli (even in the absence of reinforcement). (C) 2000 Elsevier Science B.V. All rights reserved.