MBT domain proteins in development and disease.
MBT domain proteins in development and disease.
复制标题
DOI：
10.1016/j.semcdb.2009.09.010
复制
发表时间：
2010-04
影响因子：
7.3
通讯作者：
Reinberg D
中科院分区：
文献类型：
--
作者：
Bonasio R;Lecona E;Reinberg D
The Malignant Brain Tumor (MBT) domain is a “chromatin reader”, a protein module that binds to post-translational modifications on histone tails that are thought to affect a variety of chromatin processes, including transcription. More specifically, MBT domains recognize mono- and di-methylated lysines at a number of different positions on histone H3 and H4 tails. Three Drosophila proteins, SCM, L(3)MBT and SFMBT contain multiple adjacent MBT repeats and have critical roles in development, maintenance of cell identity, and tumor suppression. Although they function in different pathways, these proteins all localize to chromatin in vivo and repress transcription by a currently unknown molecular mechanism that requires the MBT domains. The human genome contains several homologues of these MBT proteins, some of which have been linked to important gene regulatory pathways, such as E2F/Rb- and Polycomb-mediated repression, and to the insurgence of certain neurological tumors. Here, we review the genetics, biochemistry, and cell biology of MBT proteins and their role in development and disease.
登录
查看更多内容
影响因子：
7.7
作者：
Grimm, Clemens;de Ayala Alonso, Andres Gaytan;Mueller, Christoph W.
通讯作者：
Mueller, Christoph W.
影响因子：
8
作者：
Koga, H;Matsui, S;Saya, H
通讯作者：
Saya, H
MBT 重复蛋白 L3MBTL2 对组蛋白的甲基化状态特异性识别
影响因子：
14.9
作者：
Guo Y;Nady N;Qi C;Allali-Hassani A;Zhu H;Pan P;Adams-Cioaba MA;Amaya MF;Dong A;Vedadi M;Schapira M;Read RJ;Arrowsmith CH;Min J
通讯作者：
Min J
影响因子：
11.4
作者：
Grimm, Clemens;Matos, Raquel;Ly-Hartig, Nga;Steuerwald, Ulrich;Lindner, Doris;Rybin, Vladimir;Mueller, Juerg;Mueller, Christoph W.
通讯作者：
Mueller, Christoph W.
影响因子：
11.4
作者：
Arai, S;Miyazaki, T
通讯作者：
Miyazaki, T