Moderate Intensity, but Not High Intensity, Treadmill Exercise Training Alters Power Output Properties in Myocardium From Aged Rats
Moderate Intensity, but Not High Intensity, Treadmill Exercise Training Alters Power Output Properties in Myocardium From Aged Rats
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DOI：
10.1093/gerona/gls146
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发表时间：
2012-11-01
影响因子：
5.1
通讯作者：
Diffee, Gary M.
中科院分区：
文献类型：
--
作者：
Chung, Eunhee;Diffee, Gary M.
衰老的特点是心脏功能逐渐衰退，但耐力运动训练已被证明可以延缓衰老的许多有害影响。然而，运动训练改善与年龄相关的心肌收缩功能下降的潜在机制尚不清楚。本研究的目的是确定运动训练对老年大鼠透化（剥皮）肌细胞功率输出特性的影响。 30 个月大的大鼠被分为久坐对照组 (C) 和接受 11 周中等强度 (MI) 和高强度 (HI) 跑步机运动训练的组。与 C 相比，归一化为最大力的峰值功率输出在 MI 中显着增加，但在 HI 中没有显着增加，心室中心房肌球蛋白轻链 1 显着增加。这些结果表明，MI 运动训练是有益的，因为可以显着提高心肌做功的能力，但 HI 训练却没有看到这种效果。
Aging is characterized by a progressive decline in cardiac function, but endurance exercise training has been shown to retard a number of deleterious effects of aging. However, underlying mechanisms by which exercise training improves age-related decrements in myocardial contractile function are not well understood. The purpose of this study was to determine the effects of exercise training on power output properties in permeablized (skinned) myocytes of old rats. Thirty-month-old rats were divided into sedentary control (C) and groups undergoing 11 weeks of treadmill exercise training at moderate intensity (MI) and at high intensity (HI). Peak power output normalized to maximal force was significantly increased in MI but not in HI compared to C with significant increases in atrial myosin light chain 1 in ventricle. These results suggest that MI exercise training is beneficial as a significant increase was seen in the ability of the myocardium to do work, but this effect was not seen with HI training.