Droplet microfluidics based microseparation systems.
Droplet microfluidics based microseparation systems.
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DOI：
10.1002/jssc.201200115
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发表时间：
2012-06
影响因子：
3.1
通讯作者：
Zhiliang Xiao;Menglei Niu;Bo Zhang
中科院分区：
文献类型：
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作者：
Zhiliang Xiao;Menglei Niu;Bo Zhang
芯片实验室(LOC)技术是一种很有前途的小型化方法。它显著减少了样品消耗，这一特点在分析和生物分析化学中具有重要意义。自LOC技术问世以来，连续流微流控系统一直是人们关注的焦点。在世纪之交，出现了液滴微流体，又称分段流微流体。液滴微流体利用两个不相容的相形成离散的液滴，是体积受限、分散受限、交叉污染有限、比表面积大的理想容器。由于这些独特的特性，液滴微流体被证明是微尺度样品处理中的一种通用工具。本文综述了液滴微流控技术在微分析系统中的应用，重点介绍了分离科学，包括超小体积样品的封装、分离带的划分、液滴含量的分离以及相关的检测技术。
Lab on a chip (LOC) technology is a promising miniaturization approach. The feature that it significantly reduced sample consumption makes great sense in analytical and bioanalytical chemistry. Since the start of LOC technology, much attention has been focused on continuous flow microfluidic systems. At the turn of the century, droplet microfluidics, which was also termed segmented flow microfluidics, was introduced. Droplet microfluidics employs two immiscible phases to form discrete droplets, which are ideal vessels with confined volume, restricted dispersion, limited cross-contamination, and high surface area. Due to these unique features, droplet microfluidics proves to be a versatile tool in microscale sample handling. This article reviews the utility of droplet microfluidics in microanalytical systems with an emphasize on separation science, including sample encapsulation at ultra-small volume, compartmentalization of separation bands, isolation of droplet contents, and related detection techniques.