Variability of native T1 values: implication for defining regional myocardial changes using MRI
Variability of native T1 values: implication for defining regional myocardial changes using MRI
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DOI：
10.1007/s10554-018-1371-8
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发表时间：
2018-10-01
影响因子：
2.1
通讯作者：
Carr, James C.
中科院分区：
文献类型：
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作者：
Lin, Kai;Suwa, Kenichiro;Carr, James C.
本研究的目的是建立利用磁共振成像(MRI)重复测量左心室(LV)局部T1值的T1变异阈值(T1V)。18名健康志愿者接受了连续两次心脏MRI扫描，采用改良Look-Locker Invertion Recovery(MOLLI)技术，在不同的时间重复测量左心室的T1。用两个扫描仪和两个阅读器获得区域T1值的绝对差值(D)和标准差(Sds)。计算T1V阈值(平均差值+2SD)、组内相关系数(ICC)和变异系数(CoV)。使用Molli序列(具有多个空间分辨率)在所有18名志愿者中成功地进行了两次T1标测。在每个层面上，观察者内、观察者间、观察者间和研究间t1V的ICC分别为0.988、0.899、0.763和0.60。变异系数分别为0.72、2.39、3.90和4.28%。T1V阈值分别为22、66、118和120ms。在每个部分的基础上，观察者内、观察者间、分辨率间和研究间T1v的ICC分别为0.974、0.859、0.711和0.594。变异系数分别为1.09、3.36、4.69和5.01%。T1V阈值分别为33、94、140和144ms。这些阈值可能有助于区分疾病引发的t1V和t1测量的随机误差。
The aim of the present study was to establish T1 variation (T1v) thresholds for duplicated measurements of regional T1 values in left ventricle (LV) using magnetic resonance imaging (MRI). Eighteen healthy volunteers were recruited to undergo two consecutive cardiac MRI scans using modified Look-Locker Inversion recovery (MOLLI) with two spatial resolutions on different days to repeat T1 measurements on LV. The absolute differences (d) and standard deviations (SDs) of regional T1 values were acquired with the two scans and two readers. T1v threshold (mean difference+2SD), intra-class correlation coefficient (ICC) and coefficient of variation (CoV) were calculated. T1 mapping using the MOLLI sequence (with multiple spatial resolutions) was successfully performed in all 18 volunteers twice. On a per-slice basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-study T1v were 0.988, 0.899, 0.763 and 0.6. CoVs were 0.72, 2.39, 3.90 and 4.28%. T1v thresholds were 22, 66, 118 and 120ms. On a per-segment basis, ICCs for intra-observer, inter-observer, inter-resolution and inter-studyT1v were 0.974, 0.859, 0.711 and 0.594. CoVs were 1.09, 3.36, 4.69 and 5.01%. T1v thresholds were 33, 94, 140 and 144ms. Those thresholds may be useful for discriminating disease-initiated T1v from random errors of T1 measurements.