An immune stress test for resilience to aging: Pneumococcal vaccine response.
An immune stress test for resilience to aging: Pneumococcal vaccine response.
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DOI：
10.31491/apt.2020.09.035
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发表时间：
2020-09-29
期刊：
影响因子：
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通讯作者：
Ladiges WC
中科院分区：
文献类型：
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作者：
Oveson R;Jiang Z;Izhaky M;Sharma K;Ladiges WC
早年对身体压力的反应程度可以用来衡量晚年的健康状况，这是一种更好地定义对衰老的韧性的新方法。为此，对中年(15月龄)小鼠进行了商品肺炎球菌疫苗(Prevnar 13)的免疫应激，30天后用ELISA法将其分为高抗体应答组和低抗体应答组，检测免疫球蛋白血清抗体水平。4个月后对小鼠的生理表现和学习能力进行评估。高抗体反应组能够比低抗体反应组在转杆上停留的时间更长，并且能够更快地在空间导航学习任务中找到逃生洞。这一观察表明，中年时期的Prevnar 13抗体反应可能是一种有用的压力测试，可以预测健康老龄化。
The idea that the degree of response to physical stress in early life can be used to measure health in later life is a novel approach to better define resilience to aging. To investigate this, middle-age (15 months) mice were stressed by vaccination with a commercial pneumococcal vaccine (Prevnar 13), and 30 days later separated into a high antibody response group and a low antibody response group using Elisa to detect IgG serum antibody levels. After 4 months, mice were evaluated for physiological performance and learning ability. The high antibody response group was able to stay on a rotating rod longer than the low antibody response group and were more quickly able to find the escape hole in a spatial navigation learning task. This observation suggests Prevnar 13 antibody response in midlife could be a useful stress test to predict healthy aging.