Perinatal brain injury in the preterm and term newborn
Perinatal brain injury in the preterm and term newborn
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DOI：
10.1097/00019052-200204000-00005
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发表时间：
2002-04-01
影响因子：
4.8
通讯作者：
Volpe, JJ
中科院分区：
文献类型：
--
作者：
du Plessis, AJ;Volpe, JJ
在理解脑损伤的细胞机制方面的重大进展已经提出了许多潜在的干预目标。缺氧缺血性损伤是围产期脑损伤的最重要形式，尤其如此。由于胎儿和新生儿中有效临床干预的窗口可能特别窄，因为损伤的发作通常延迟和微妙，最近的重点是定义和对抗脑损伤的延迟机制。最近的见解少突胶质细胞损伤的机制和炎症物质在围产期脑损伤的作用进行了讨论。
Major advances in understanding the cellular mechanisms of brain injury have presented a host of potential targets for intervention. This is particularly true of hypoxic-ischemic injury, the most important form of perinatal brain injury. As the window for effective clinical intervention may be particularly narrow in the fetus and newborn because of the often-delayed and subtle presentation of the onset of the insult, recent focus has been on defining and countering the more delayed mechanisms of brain injury. Recent insights into the mechanisms of oligodendrocyte injury and the role of inflammatory substances in perinatal brain injury are also discussed.