Self-organizing mechanism for development of space-filling neuronal dendrites
Self-organizing mechanism for development of space-filling neuronal dendrites
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DOI：
10.1371/journal.pcbi.0030212
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发表时间：
2007-11-01
影响因子：
4.3
通讯作者：
Mochizuka, Atsushi
中科院分区：
文献类型：
--
作者：
Sugimura, Kaoru;Shimono, Kohei;Mochizuka, Atsushi
神经元发展出独特的树突形态来接收和处理信息。先前的实验表明，竞争性的树突-树突相互作用在形成空间填充型树突中起着关键作用，这种树突均匀地覆盖它们的感受野。我们将这一发现纳入构建一个新的数学模型，其中两种化学物质（激活剂和抑制剂）的反应动力学耦合到神经元树突生长。我们的数值分析确定了树枝状分支的条件，并建议该系统的自组织属性可以根据树枝状。此外，我们发现了一个明确的树突形状和激活剂的分布之间的相关性，从而提供了一个形态学标准来预测在体内分布的假设分子复合物负责树突的伸长和分支。
Neurons develop distinctive dendritic morphologies to receive and process information. Previous experiments showed that competitive dendro-dendritic interactions play critical roles in shaping dendrites of the space-filling type, which uniformly cover their receptive field. We incorporated this finding in constructing a new mathematical model, in which reaction dynamics of two chemicals ( activator and suppressor) are coupled to neuronal dendrite growth. Our numerical analysis determined the conditions for dendritic branching and suggested that the self-organizing property of the proposed system can underlie dendritogenesis. Furthermore, we found a clear correlation between dendrite shape and the distribution of the activator, thus providing a morphological criterion to predict the in vivo distribution of the hypothetical molecular complexes responsible for dendrite elongation and branching.