Insights into the epigenetic effects of nanomaterials on cells
Insights into the epigenetic effects of nanomaterials on cells
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深入了解纳米材料对细胞的表观遗传效应
DOI：
10.1039/c9bm01526d
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发表时间：
2020
影响因子：
6.6
通讯作者：
Ruan Jing
中科院分区：
文献类型：
--
作者：
Yu Jie;Loh Xian Jun;Luo Yifei;Ge Shengfang;Fan Xianqun;Ruan Jing
随着纳米技术的发展，纳米材料越来越多地应用于生物医学、医药、化妆品等健康领域。因此，人们对它们的毒性提出了关切，并进行了许多研究，以评估它们的安全性。大多数关于纳米材料的毒性和治疗机制的研究都揭示了纳米材料在转录组和蛋白质组水平上对细胞的影响。然而，在基因表达调控中起重要作用的表观遗传修饰，如DNA甲基化、组蛋白修饰和纳米材料诱导的非编码RNA表达等，还没有得到足够的重视。在这篇综述中，我们阐述了研究纳米材料诱发的表观遗传学效应的重要性；然后，我们综述了纳米材料表观遗传学在毒性、治疗和其他机制方面的研究进展。并阐明了未来纳米材料表观遗传学研究的可能方向。最后，我们讨论了纳米材料表观遗传学的未来发展和仍然需要解决的挑战。我们希望通过对纳米材料表观遗传学的深入研究，了解纳米材料的潜在毒性，并清楚地了解其治疗机制。
With the development of nanotechnology, nanomaterials are increasingly being applied in health fields, such as biomedicine, pharmaceuticals, and cosmetics. Concerns have therefore been raised over their toxicity and numerous studies have been carried out to assess their safety. Most studies on the toxicity and therapeutic mechanisms of nanomaterials have revealed the effects of nanomaterials on cells at the transcriptome and proteome levels. However, epigenetic modifications, for example DNA methylation, histone modification, and noncoding RNA expression induced by nanomaterials, which play an important role in the regulation of gene expression, have not received sufficient attention. In this review, we therefore state the importance of studying epigenetic effects induced by nanomaterials; then we review the progress of nanomaterial epigenetic research in the assessment of toxicity, therapeutic, and other mechanisms. We also clarify the possible study directions for future nanomaterial epigenetic research. Finally, we discuss the future development and challenges of nanomaterial epigenetics that must still be addressed. We hope to understand the potential toxicity of nanomaterials and clearly understand the therapeutic mechanism through a thorough investigation of nanomaterial epigenetics.