Improved Synthesis of Icaritin and Total Synthesis of beta-Anhydroicaritin
Improved Synthesis of Icaritin and Total Synthesis of beta-Anhydroicaritin
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淫羊藿素的改进合成和β-脱水淫羊藿素的全合成
DOI：
10.1007/s40242-019-9012-x
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发表时间：
2019
影响因子：
3.1
通讯作者：
Wang Bo
中科院分区：
文献类型：
--
作者：
Tong Jie;Liu Chang;Wang Bo
以间苯三酚为原料，经9步反应合成了具有P-糖蛋白（P-gp）抑制活性的天然产物淫羊藿苷和β-脱水淫羊藿苷。该路线采用了改进的Algar-Flynn-Oyamada环化反应和接力Claisen-Cope重排反应。我们的合成提供了机会，合成各种淫羊藿苷类似物的生物和药理研究。
Natural products icaritin andβ-anhydroicaritin with P-glycoprotein(P-gp) inhibitory activities were efficiently synthesized in nine steps from commercially available phloroglucinol. A modified Algar-Flynn-Oyamada cyc-lization and relay Claisen-Cope rearrangement were employed in this concise route. Our synthesis offers opportunities to synthesize various icariin analogues for biological and pharmacological investigations.