Separate roles of sodium ion concentration and fluid volumes in salt-loading hypertension in sheep.
Separate roles of sodium ion concentration and fluid volumes in salt-loading hypertension in sheep.
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钠离子浓度和液体体积在绵羊盐负荷高血压中的独立作用。
DOI：
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发表时间：
1975
影响因子：
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通讯作者：
A. C. Guyton
中科院分区：
文献类型：
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作者：
R. A. Norman;TG Coleman;Wiley Tl;Manning Rd;A. C. Guyton
这些研究的目的是确定过量盐负荷引起的高血压是否是由钠诱导的细胞外液体积膨胀引起的，或者盐是否以其他方式增加压力，例如通过引起血管收缩。在一组绵羊中，采用全肾切除术和血液透析相结合的方法来产生并维持细胞外液容量的逐步增加，持续1周，而钠离子浓度没有显着变化。在第二组中，单侧肾切除术、透析和DOCA给药用于引起钠离子浓度的逐步增加，同时细胞外液体积尽可能接近正常。结果显示，高容量绵羊的动脉压增加了41%，而高钠绵羊的动脉压仅增加了4%。在这两种情况下，交换性钠的总量几乎相等地增加，高钠羊增加了21%。这些数据支持了钠潴留几乎完全是由于钠诱导的细胞外液体积膨胀而导致高血压的概念。
The goal of these studies was to determine whether the hypertension caused by excessive salt loading results from sodium-induced expansion of the extracellular fluid volume or whether the salt increases the pressure in some other way, such as by causing vascular constriction. In one group of sheep, a combination of total nephrectomy and hemodialysis was used to produce and maintain step increases in extracellular fluid volume for 1 wk without a significant change in sodium ion concentration. In a 2nd group, unilateral nephrectomy, dialysis, and DOCA administration were used to cause step increases in sodium ion concentration while the extracellular fluid volume was held as close to normal as possible. The results showed a 41% increase in arterial pressure in the high-volume sheep and only a 4% increase in pressure in the high-sodium sheep. In both instances the total exchangeable sodium increased almost equally--a 21% increase in the high-sodium sheep. The data support the concept that sodium retention causes hypertension almost entirely because of sodium-induced expansion of the extracellular fluid volume.