Transforming growth factor-beta (TGF beta) is chemotactic for human monocytes and induces their expression of angiogenic activity.
Transforming growth factor-beta (TGF beta) is chemotactic for human monocytes and induces their expression of angiogenic activity.
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转化生长因子-β (TGF beta) 对人类单核细胞具有趋化性，并诱导其表达血管生成活性。
DOI：
10.1016/s0006-291x(88)80319-x
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发表时间：
1988
影响因子：
3.1
通讯作者：
Leibovich,SJ
中科院分区：
文献类型：
--
作者：
Wiseman,DM;Polverini,PJ;Kamp,DW;Leibovich,SJ
TGFβ 刺激人血单核细胞迁移，迁移反应峰值始终出现在 16-100fg/ml 的浓度下。棋盘分析揭示了这种反应的趋化和趋化动力学成分。在较高浓度（10-100pg/ml）下，TGFβ刺激单核细胞表达血管生成活性。虽然在静息单核细胞中检测不到 TNFα mRNA，但在 TGFβ 处理的单核细胞中迅速诱导出高稳态水平的 TNFαmRNA。 TGFβ由许多肿瘤细胞以及正常细胞（例如血小板和淋巴细胞）分泌。 TGFβ可以从循环中招募单核细胞，随后激活它们表达TNFα等血管生成活性，从而在伤口修复、炎症和肿瘤生长中发挥重要作用。
TGFβstimulates human blood monocyte migration, with peak migratory response occurring consistently at a concentration of 16–100fg/ml. Checkerboard analysis revealed both chemotactic and chemokinetic components to this response. At higher concentrations (10–100pg/ml), TGFβstimulated expression of angiogenic activity by monocytes. While mRNA for TNFαwas undetectable in resting monocytes, high steady state levels of TNFαmRNA were rapidy induced in TGFβ-treated monocytes. TGFβis secreted by a number of neoplastic cells as well as normal cells such as platelets and lymphocytes. TGFβmay recruit monocytes from the circulation, and subsequently activate them to express angiogenic activities such as TNFα, thus playing an important role in wound repair, inflammation and tumor growth.