Does iron have a role in breast cancer?
Does iron have a role in breast cancer?
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铁在乳腺癌中有作用吗？
DOI：
10.1016/s1470-2045(08)70200-6
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发表时间：
2008-08
期刊：
影响因子：
51.1
通讯作者：
Huang, Xi
中科院分区：
文献类型：
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作者：
Huang, Xi
雌激素和家族史是乳腺癌的两个最重要的危险因素。然而，这些危险因素不能解释绝经前和绝经后妇女乳腺癌发病率和复发率的差异。在本文中，我提出，在绝经前妇女中，月经引起的铁缺乏稳定了缺氧诱导因子-1 α，从而增加了血管内皮生长因子的形成。这种机制导致绝经前妇女更容易发生血管生成，因此导致乳腺癌的高复发率。相反，绝经后妇女由于月经停止而增加的铁浓度通过氧化应激途径导致乳腺癌的高发病率。虽然这个个人观点的重点是铁，但这绝不否定其他已知的风险因素在乳腺癌发展中的作用。铁在乳腺癌中作用的特征可能通过降低复发率和发病率以及增加总生存率而使患者受益。
Oestrogen and family history are two of the most important risk factors for breast cancer. However, these risk factors cannot explain the differences in the incidence and recurrence of breast cancer between premenopausal and postmenopausal women. In this paper I propose that, in premenopausal women, an iron deficiency caused by menstruation stabilises hypoxia inducible factor-1α, which increases the formation of vascular endothelial growth factor. This mechanism results in premenopausal women being more susceptible to angiogenesis and, consequently, leads to a high recurrence of breast cancer. Conversely, increased concentrations of iron in post menopausal women, as a result of menstrual cessation, contribute to a high incidence of breast cancer via oxidative-stress pathways. Although the focus of this Personal View is on iron, this by no means negates the roles of other known risk factors in breast-cancer development. Characterisation of the role of iron in breast cancer could potentially benefit patients by decreasing recurrence and incidence and increasing overall survival.