Antioxidant activities of polysaccharides from Hyriopsis cumingii
Antioxidant activities of polysaccharides from Hyriopsis cumingii
复制标题
三角帆蚌多糖的抗氧化活性
DOI：
10.1016/j.carbpol.2009.03.018
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发表时间：
2009-09-05
影响因子：
11.2
通讯作者：
Zeng, Xiaoxiong
中科院分区：
文献类型：
--
作者：
Qiao, Deliang;Ke, Chunling;Zeng, Xiaoxiong
对三角帆蚌粗多糖(HCPS)的体外和体内抗氧化活性进行了研究。体外抗氧化实验表明，HCPS粗品及其精制部分能清除过氧化氢、超氧阴离子和2，2-二苯基-1-苦皮酰肼自由基，并能螯合亚铁离子，还原铁离子。除金属离子螯合活性外，HCPS-3的抗氧化活性明显高于粗品HCPS、HCPS-1和HCPS-2。为了体内抗氧化测试，在D-半乳糖诱导的衰老小鼠模型中，给予不同剂量的粗制羟基喜树碱15天。结果表明，HCPS粗品可显著抑制小鼠肝脏和血清中丙二醛的生成，提高抗氧化酶活性和总抗氧化能力，并呈剂量依赖关系。结果表明，HCPS具有直接而有效的抗氧化活性。(C)2009爱思唯尔有限公司。保留所有权利。
The antioxidant activities of crude Hyriopsis cumingii polysaccharides (HCPS) were evaluated both in vitro and in vivo. In vitro antioxidant assay, HCPS (crude and its purified fraction) could scavenge hydrogen peroxide, free radicals of superoxide anion and 2,2-diphenyl-1-picryl-hydrazyl, chelate ferrous ion and reduce ferric ion. Except for metal ion chelating activity, HCPS-3 exhibited much higher antioxidant activities than crude HCPS, HCPS-1 and HCPS-2. For antioxidant testing in vivo, different doses of crude HCPS were orally administrated over a period of 15 days in a D-galactose induced aged mice model. As results, administration of crude HCPS inhibited significantly the formation of malondialdehyde in mice livers and serums and raised the activities of antioxidant enzymes and total antioxidant capacity in a dose-dependent manner. The results suggested that HCPS had direct and potent antioxidant activities. (C) 2009 Elsevier Ltd. All rights reserved.