Class 3 semaphorins and their receptors in physiological and pathological angiogenesis
Class 3 semaphorins and their receptors in physiological and pathological angiogenesis
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DOI：
10.1042/bst20110654
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发表时间：
2011-12-01
影响因子：
3.9
通讯作者：
Staton, Carolyn A.
中科院分区：
文献类型：
--
作者：
Staton, Carolyn A.
3类信号蛋白（Sema3）是一个分泌性蛋白家族，其最初被鉴定为轴突导向因子，通过与神经毡蛋白和丛蛋白形成复合物来介导其信号转导。然而，Sema3的广泛表达模式表明除了与神经系统相关的功能之外还有其他功能，事实上，许多研究表明Sema3蛋白及其受体在血管生成中发挥作用。本综述特别关注最近的证据表明，这种作用在生理和病理血管生成。
Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified as axon guidance factors mediating their signal transduction by forming complexes with neuropilins and plexins. However, the wide expression pattern of Sema3 suggested additional functions other than those associated with the nervous system, and indeed many studies have now indicated that Sema3 proteins and their receptors play a role in angiogenesis. The present review specifically focuses on recent evidence for this role in both physiological and pathological angiogenesis.