The effect of phencyclidine and DL-2-amino-5-phosphonovaleric acid on N-methyl-D-aspartic acid induced changes in extracellular concentration of dopamine and DOPAC in the rat neostriatum.
The effect of phencyclidine and DL-2-amino-5-phosphonovaleric acid on N-methyl-D-aspartic acid induced changes in extracellular concentration of dopamine and DOPAC in the rat neostriatum.
复制标题
苯环己哌啶和 DL-2-氨基-5-磷酸戊酸对 N-甲基-D-天冬氨酸的影响引起大鼠新纹状体细胞外多巴胺和 DOPAC 浓度的变化。
DOI：
10.1016/0028-3908(92)90021-g
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发表时间：
1992
影响因子：
4.7
通讯作者：
Howard,S
中科院分区：
文献类型：
--
作者：
Marek,P;Chapman,CD;Howard,S
用在体微透析技术研究了N-甲基-D-天冬氨酸（NMDA）和苯环己哌啶（PCP）对大鼠纹状体细胞外多巴胺（DA）和二羟苯乙酸（DOPAC）水平的影响。纹状体内注入NMDA产生一个显着的剂量依赖性增加细胞外DA和DOPAC的浓度下降。而2-氨基-5-膦酰基戊酸酯（APV）和PCP拮抗NMDA诱导的细胞外DA水平的增加，对NMDA诱导的细胞外DOPAC浓度的变化的影响是不同的两种化合物。APV显着衰减细胞外的DOPAC产生的较小浓度的NMDA的减少，而PCP没有阻止任何浓度的NMDA产生的DOPAC减少。苯环己哌啶单独产生剂量依赖性增加细胞外DA，但对DOPAC的细胞外浓度没有影响。这项研究表明，PCP，在浓度不产生增加细胞外DA，拮抗NMDA对DA的影响。数据还表明，APV和PCP拮抗NMDA诱发的DA释放的浓度范围内的NMDA，即使他们这样做的不同机制。
The effects of N-methyl-d-aspartic acid (NMDA) and phencyclidine (PCP) on extracellular levels of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in the striatum of the rat were studied using in vivo microdialysis. Intrastriatal infusion of NMDA produced a significant dose-dependent increase in extracellular DA and a decrease in concentrations of DOPAC. Whereas both 2-amino-5-phosphonovalerate (APV) and PCP antagonized the NMDA-induced increase in extracellular levels of DA, the effect on NMDA-induced changes in extracellular concentrations of DOPAC were different for the two compounds. The APV significantly attenuated the decrease in extracellular DOPAC produced by smaller concentrations of NMDA, whereas PCP did not prevent decrease in DOPAC produced by any concentrations of NMDA. Phencyclidine alone produced a dose-dependent increase in extracellular DA but had no effect on the extracellular concentration of DOPAC. This study demonstrated that PCP, at concentrations which did not produce an increase in extracellular DA, antagonized the effect of the NMDA on DA. The data also indicated that both APV and PCP antagonized the NMDA-evoked release of DA over a range of concentrations of NMDA, even though they did so by different mechanisms.