Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects
Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects
复制标题
中国老年甲状腺功能正常受试者甲状腺功能与肌少症的关系
DOI：
10.1007/s40520-018-1057-z
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发表时间：
2019-08-01
影响因子：
4
通讯作者：
Duan, Yu
中科院分区：
文献类型：
--
作者：
Sheng, Yunlu;Ma, Dan;Duan, Yu
目的随着世界范围内老龄化人口的增加，骨质疏松症的发病率也在增加。甲状腺激素是重要的调节剂，可以影响身体成分和身体机能。易患甲状腺功能正常的老年受试者中，甲状腺激素水平与骨质疏松症之间的关系尚不清楚。本研究旨在探讨甲状腺激素水平对老年甲状腺功能正常受试者肌力和肌力的影响。方法94例老年甲状腺功能正常受试者，男73例，女21例，均无明显影响肌肉代谢或甲状腺功能的药物或疾病。用免疫分析法检测血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)的浓度。用双能X线骨密度仪测定附肢骨骼肌质量(ASM)。结果握力和SPPB与年龄呈负相关，FT3呈年龄依赖性下降。皮尔逊相关分析显示FT3与ASM、握力、SPPB呈正相关。在甲状腺功能正常的受试者中，FT4和TSH均与这些参数无关。在调整了年龄、性别和BMI的多元线性回归分析中，FT3与ASM、握力、SPPB呈显著正相关，而FT4、TSH与上述4项骨质疏松症指标无显著相关性。骨质疏松症患者FT3水平较低。结论老年患者FT3水平在正常范围内升高与肌肉质量和肌肉功能有关。
ObjectivesWith the increase in aging population worldwide, the incidence of sarcopenia is also increasing. Thyroid hormones are important regulators that can affect body composition and physical function. The association between thyroid hormone levels and sarcopenia in susceptible elderly euthyroid subjects remains unclear. In this study, we investigated the effect of thyroid hormone concentrations on body muscle mass, muscle strength and physical function related to sarcopenia in elderly Chinese euthyroid subjects.MethodsA total of 94 elderly Chinese euthyroid subjects (73 men, 21 women) without medications or diseases which obviously affected muscle metabolism or thyroid function were included in our study. Concentrations of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were determined by immunoassays. Appendicular skeletal muscle mass (ASM) was assessed by dual-energy X-ray absorptiometry. Handgrip strength was measured using a Jamar hand dynamometer, and physical function was assessed by the Short Physical Performance Battery (SPPB).ResultsMuscle function, both handgrip strength and SPPB, was negatively associated with age, and FT3 demonstrated age-dependent decline. Pearson’s correlation analysis showed positive associations of FT3 with ASM, handgrip strength and SPPB. Neither FT4 nor TSH was associated with these parameters of sarcopenia in euthyroid subjects. Significantly positive correlations between FT3 and ASM, handgrip strength and SPPB were also observed in multiple linear regression analysis adjusted for age, gender and BMI, while no significant correlations were found between FT4 or TSH and aforementioned four parameters of sarcopenia. Subjects with sarcopenia had lower level of FT3.ConclusionsHigher FT3 concentration within normal range was correlated to muscle mass and muscle function in elderly subjects.