Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumours?
Does mean lung dose calculated after inhalation of alpha emitters actually reflect the risk of induction of malignant lung tumours?
复制标题
吸入α发射体后计算出的平均肺部剂量是否确实反映了诱发恶性肺部肿瘤的风险？
DOI：
10.1093/oxfordjournals.rpd.a006211
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发表时间：
2003
影响因子：
1
通讯作者：
G. Monchaux
中科院分区：
文献类型：
--
作者：
P. Fritsch;N. Dudoignon;K. Guillet;Y. Oghiso;J. Morlier;G. Monchaux
在吸入含有不同物理化学性质的α发射器的气溶胶后，对大鼠肺肿瘤的发病率进行了比较。将氡及其子代、铀矿尘、NpO2、PuO2或Cm2O3等气溶胶进行了相似或不同粒径的对比。恶性肺肿瘤频率的剂量-效应关系在几戈瑞以内呈线性，然后在高剂量照射到肺部时变为非线性。曲线的初始斜率反映了诱发肺肿瘤的风险。氡和铀矿石粉尘的发病率斜率最高（分别约为70 Gy和20% Gy(-1)），预计肺部的α剂量分布最均匀。总的趋势是，增加沉积粒子的α -活性（组成放射性同位素的比活性较高或粒子尺寸较大）可降低风险。对报告数据的比较表明，“低剂量”下每戈瑞的风险可能根据气溶胶的物理化学性质变化一个数量级以上。
A comparison of incidence of lung tumours in rats after inhalation exposure to aerosols containing alpha emitters which have different physico-chemical properties has been performed. Aerosols of radon and progeny, uranium ore dust, NpO2, PuO2 or Cm2O3 were considered for intercomparison with similar or different particle sizes. Dose-effect relationships for the frequency of malignant lung tumours appear linear up to a few Gy and then become infralinear at higher doses delivered to the lungs. The initial slope of the curves reflects the risk of induction of a lung tumour. The highest slopes of incidence were observed for radon and uranium ore dust (about 70 and 20% Gy(-1) respectively) for which the most homogeneous alpha dose distribution to the lungs is expected. In a general trend, increasing the alpha-activity of deposited particles (higher specific activity of constituent radioisotopes or larger particle size) decreases the risk. The comparison of the reported data shows that the risk per Gy at 'low doses' could vary over more than one order of magnitude depending on the physico-chemical properties of the aerosols.