Motor cortex disinhibition in acute stroke
Motor cortex disinhibition in acute stroke
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DOI：
10.1016/s1388-2457(99)00312-0
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发表时间：
2000-04-01
影响因子：
4.7
通讯作者：
Weiller, C
中科院分区：
文献类型：
--
作者：
Liepert, J;Storch, P;Weiller, C
目的：为了测试是否发生在人类运动皮层的去抑制后stroke.Methods：急性单侧缺血性中风后轻中度偏瘫患者与年龄匹配的健康对照进行了比较。我们使用成对的经颅磁刺激（TMS）来研究皮质内抑制和易化。单TMS被施加到获得一个皮层的沉默periods.Results：皮层内抑制显着减少在受影响的半球在刺激间隔为2，3和4毫秒。皮层沉默期显着延长时相比，未受影响的半球的患者和对照组。运动皮层去抑制中风患者中观察到的是与最小的损害在症状发作或迅速改善运动functions.Conclusions：运动皮层去抑制发生在人类中风后。我们认为，这种去抑制是指示补偿机制，这是参与恢复相关的重组。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: To test whether a disinhibition occurs in the human motor cortex after stroke.Methods: Patients with a mild to moderate hemiparesis after an acute unilateral ischemic stroke were compared with age-matched healthy controls. We used paired transcranial magnetic stimuli (TMS) to investigate intracortical inhibition and facilitation. Single TMS were applied to obtain a cortical silent period.Results: Intracortical inhibition was significantly reduced in the affected hemisphere at interstimulus intervals of 2, 3 and 4 ms. The cortical silent period was significantly prolonged when compared to the unaffected hemisphere of the patients and to the control group. Motor cortex disinhibition observed in stroke patients was associated either with minimal impairment at the onset of symptoms or with rapidly improving motor functions.Conclusions: Motor cortex disinhibition occurs in humans after stroke. We suggest that this disinhibition is indicative of compensatory mechanisms, which are involved in recovery-related reorganization. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.