Dynamic Changes in the Canine Mitral Regurgitant Orifice Area during Ventricular Ejection
Dynamic Changes in the Canine Mitral Regurgitant Orifice Area during Ventricular Ejection
复制标题
心室射血时犬二尖瓣反流口面积的动态变化
DOI：
10.1161/01.res.45.5.677
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发表时间：
1979
影响因子：
20.1
通讯作者：
R. Frater
中科院分区：
文献类型：
--
作者：
E. Yellin;C. Yoran;E. Sonnenblick;S. Gabbay;R. Frater
本研究旨在验证急性二尖瓣反流时二尖瓣反流面积（MRA）是一个随心室容积时间变化的动态量的假设。在5只开胸犬中创建了二尖瓣关闭不全，其中切除了前叶的一部分。通过电磁法测量相位性主动脉和二尖瓣血流，沿着左心房！和心室压力。充盈量、舒张量、每搏输出量和收缩压梯度通过数字方法测定。根据流体动力学运动方程计算MRA，以给出三个时刻和峰值流量时（惯性可忽略时）的时间平均值和瞬时值。平均抗心律失常分数为42 ± 12%，无容量超负荷导致的左心室衰竭迹象。MRA随时间单调下降至初始值的59%，并密切跟踪收缩期心室容积的减少。在一项对照研究中，使用了一个在封堵器上有一个直径为5 mm的孔的倾斜盘假体，计算的MRA是时不变的，等于测量的反流面积。我们的结论是，在急性二尖瓣返流的MRA是心室容积的函数。Circ Res 45：677-683，1979年
We designed this study to test the hypothesis that in acute mitral regurgitation the mitral regurgitant area (MRA) is a dynamic quantity which varies with the time variation of ventricular volume. Mitral insufficiency was created in five open-chest dogs in which a portion of the anterior leaflet was excised. Phasic aortic and mitral flows were measured electromagnetically, along with left atria! and ventricular pressures. Filling, regurgitant, and stroke volumes, and systolic pressure gradient were determined by digital methods. MRA was calculated from the fluid dynamic equation of motion to give the temporal mean and the instantaneous value at three instants of time and at the time of peak flow (when inertia is negligible). Mean regurgitant fraction was 42 ± 12% with no indication of left ventricular failure due to volume overload. MRA decreased monotonically with time to 59% of its initial value and closely paralleled the decrease in ventricular volume during systole. In a control study using a tilting-disc prosthesis with a hole 5 mm in diameter in the occluder, the calculated MRA was time invariant and equal to the measured area for regurgitation. We conclude that in acute mitral regurgitation the MRA is a function of ventricular volume. Circ Res 45: 677-683, 1979