Fullerene-biomolecule conjugates and their biomedicinal applications.
Fullerene-biomolecule conjugates and their biomedicinal applications.
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DOI：
10.2147/ijn.s52829
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发表时间：
2014
影响因子：
8
通讯作者：
Cui Q
中科院分区：
文献类型：
--
作者：
Yang X;Ebrahimi A;Li J;Cui Q
富勒烯是最强的抗氧化剂之一，被称为“自由基海绵”。自1993年Friedman等人发表了具有里程碑意义的论文以来，富勒烯的生物医学应用研究取得了重大进展。富勒烯-生物分子偶联物是近二十年来研究的一个重要领域。通过彻底的文献检索，我们试图更新有关不同类型富勒烯-生物分子缀合物合成的信息，包括含富勒烯的氨基酸和肽、寡核苷酸、糖和酯。此外，我们还讨论了最近报道的数据，这些化合物和其他一些富勒烯衍生物的生物医学重要性的生物和医药效用。而在富勒烯-生物分子缀合物中，其中富勒烯可以充当抗氧化剂和载体，与富勒烯缀合的特异性靶向生物分子无疑将加强功能性富勒烯向临床感兴趣部位的递送。
Fullerenes are among the strongest antioxidants and are characterized as “radical sponges.” The research on biomedicinal applications of fullerenes has achieved significant progress since the landmark publication by Friedman et al in 1993. Fullerene–biomolecule conjugates have become an important area of research during the past 2 decades. By a thorough literature search, we attempt to update the information about the synthesis of different types of fullerene–biomolecule conjugates, including fullerene-containing amino acids and peptides, oligonucleotides, sugars, and esters. Moreover, we also discuss in this review recently reported data on the biological and pharmaceutical utilities of these compounds and some other fullerene derivatives of biomedical importance. While within the fullerene–biomolecule conjugates, in which fullerene may act as both an antioxidant and a carrier, specific targeting biomolecules conjugated to fullerene will undoubtedly strengthen the delivery of functional fullerenes to sites of clinical interest.