Photodynamic therapy using topical toluidine blue for the treatment of oral leukoplakia: A prospective case series
Photodynamic therapy using topical toluidine blue for the treatment of oral leukoplakia: A prospective case series
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DOI：
10.1016/j.pdpdt.2020.101888
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发表时间：
2020-09-01
影响因子：
3.3
通讯作者：
Lucchese, Alberta
中科院分区：
文献类型：
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作者：
Di Stasio, Dario;Romano, Antonio;Lucchese, Alberta
背景：光动力疗法（PDT）是一种通过暴露于特定波长光源后激活光敏剂来治疗口腔白斑（OL）的微创方法。方法：研究甲苯胺蓝作为局部光敏剂的有效性。 11名患者参与了这项研究；使用 2.5% 甲苯胺蓝和 630 nm 波长的 LED 光源分几次治疗 15 个口腔白斑病变。在基线（t0）、治疗周期结束时（t1）和治疗结束后一年（t2）对患者进行评估。每次访问时对所有处理部位进行拍照。用ImageJ 1.52软件处理图像以获得治疗病变的面积(mm2)。采用配对T检验对不同随访数据进行比较。结果：t1时，6个病灶获得完全缓解，7个病灶部分缓解，只有2个病灶无缓解。在 t2 时，两名患者观察到进一步改善。区域分析显示，从 t0 到 t1（p = 0.003）以及从 t1 到 t2（p = 0.01），病灶大小显着减小。结论：甲苯胺蓝似乎是口腔白斑光动力治疗中一种有前途的光敏剂。
Background: Photodynamic therapy (PDT) is a minimally invasive method for the treatment of oral leukoplakia (OL) through the activation of a photosensitizer, after exposure to a specific wavelength light source.Methods: To investigate the effectiveness of toluidine blue as topical photosensitizer. Eleven patients participated in this study; fifteen oral leukoplakia lesions were treated, in several sessions, with 2.5 % toluidine blue and an LED source of 630 nm wavelength. Patients were evaluated at baseline (t0), at the end of treatment cycles (t1) and one year from the end of treatment (t2). All the treated sites were photographed at each visit. Images were processed with ImageJ 1.52 software in order to obtain the areas (mm2) of the treated lesions. Comparison between data at different follow-up was performed using a paired T-test.Results: At t1, complete response was obtained in six lesions, partial response in seven lesions while only two lesions showed no response. At t2, a further improvement was observed in two patients. The analysis of the areas showed significant reduction of the lesion size from t0 to t1 (p = 0.003), and from t1 to t2 (p = 0.01).Conclusion: Toluidine blue appears to be a promising photosensitizer in the photodynamic therapy of oral leukoplakia.