A computational framework for investigating the positional stability of aortic endografts.
A computational framework for investigating the positional stability of aortic endografts.
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DOI：
10.1007/s10237-012-0450-3
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发表时间：
2013-10
影响因子：
3.5
通讯作者：
Figueroa, C. Alberto
中科院分区：
文献类型：
--
作者：
Prasad, Anamika;Xiao, Nan;Gong, Xiao-Yan;Zarins, Christopher K.;Figueroa, C. Alberto
血管内动脉瘤修复(Greenhalgh，Brown等人)这些技术彻底改变了胸腹主动脉瘤的治疗方法，极大地降低了与开放手术修复技术相关的围手术期死亡率和发病率。然而，EVAR也不是没有重要的并发症，如延迟的装置迁移、内漏形成和装置部件断裂，这些并发症可能导致动脉瘤扩大、需要长期的影像监视和二次干预甚至死亡等不良事件。这些并发症是由于该装置不能承受血流的血流动力学，不能随着时间的推移保持其手术后的原定位置。了解内移植物所经历的体内生物力学工作环境是提高其长期性能的关键因素。到目前为止，还没有研究在三维环境下研究装置与主动脉之间的接触机制。在这项工作中，我们开发了一个全面的计算固体力学和计算流体力学框架，以研究内植骨位置稳定性的力学。该框架的主要组成部分是：i)三维非平面的主动脉和支架-移植物几何模型，ii)真实的多材料本构关系，iii)血流和压力的生理值，以及iv)描述移植物与主动脉之间接触的摩擦模型。我们引入了一种新的度量方法，用于内移植物位置稳定性的数值量化。最后，在结果部分，我们通过调查几个临床上已知的影响内膜移植物稳定性的因素的影响来测试该框架。
Endovascular aneurysm repair (Greenhalgh, Brown et al.) techniques have revolutionized the treatment of thoracic and abdominal aortic aneurysm disease, greatly reducing the perioperative mortality and morbidity associated with open surgical repair techniques. However, EVAR is not free of important complications such as late device migration, endoleak formation and fracture of device components that may result in adverse events such as aneurysm enlargement, need for long-term imaging surveillance and secondary interventions or even death. These complications result from the device inability to withstand the hemodynamics of blood flow and to keep its originally intended post-operative position over time. Understanding the in vivo biomechanical working environment experienced by endografts is a critical factor in improving their long-term performance. To date, no study has investigated the mechanics of contact between device and aorta in a three-dimensional setting. In this work, we developed a comprehensive Computational Solid Mechanics and Computational Fluid Dynamics framework to investigate the mechanics of endograft positional stability. The main building blocks of this framework are: i) Three-dimensional non-planar aortic and stent-graft geometrical models, ii) Realistic multi-material constitutive laws for aorta, stent, and graft, iii) Physiological values for blood flow and pressure and iv) Frictional model to describe the contact between the endograft and the aorta. We introduce a new metric for numerical quantification of the positional stability of the endograft. Lastly, in the results section, we test the framework by investigating the impact of several factors that are clinically known to affect endograft stability.
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影响因子：
4.3
作者：
Heikkinen, Maarit A.;Alsac, Jean Marc;Zarins, Christopher K.
通讯作者：
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DOI：
10.1002/nme.1825
发表时间：
2007-03-05
影响因子：
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2006-01-01
影响因子：
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作者：
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影响因子：
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作者：
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