Tremor-correlated cortical activity detected by electroencephalography
Tremor-correlated cortical activity detected by electroencephalography
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DOI：
10.1016/s1388-2457(00)00248-0
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发表时间：
2000-05-01
影响因子：
4.7
通讯作者：
Lücking, CH
中科院分区：
文献类型：
--
作者：
Hellwig, B;Häussler, S;Lücking, CH
目的：探讨脑电图（EEG）能否检测与帕金森病静息性震颤相关的皮质活动。方法：对7例特发性帕金森病单侧震颤患者进行研究。同时记录腕部伸肌和屈肌肌电信号和高分辨率脑电图。计算脑电与肌电的相干性。结果：在所有患者中，我们发现震颤肌电图和对侧脑电图通道之间的震颤频率或其第一谐波具有高度显著的一致性。震颤肌电图与同侧脑电通道无明显的一致性。等相干图显示了头皮上相干的地形，显示最大的相干位于皮质运动区。在一个病例中，在顶叶皮层也发现了高度的一致性。结论：实验结果首次显示脑电图可检测震颤相关皮层活动。研究结果强调，大脑皮层的运动区域参与了帕金森氏病中产生静息性震颤的神经网络。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
Objective: In this study we investigated whether cortical activity related to Parkinsonian resting tremor can be detected by electroencephalography (EEG).Methods: Seven patients with idiopathic Parkinson's disease suffering from unilateral tremor participated in the study. Electromyography (EMG) signals arising from the wrist extensor and flexor muscles as well as a high resolution EEG were recorded simultaneously. Coherencies between EEG and EMG were calculated.Results: In all patients, we found highly significant coherencies at the tremor frequency or its first harmonic between the tremor EMG and contralateral EEG channels. There were no significant coherencies between the tremor EMG and ipsilateral EEG channels. Isocoherency maps illustrating the topography of the coherencies over the scalp showed that the maximum coherencies were situated over the cortical motor areas. In one case, a high coherency was also found over the parietal cortex.Conclusions: The results show for the first time that tremor-correlated cortical activity can be detected by electroencephalography. The findings underline that motor areas of the cerebral cortex are involved in the neuronal network generating resting tremor in Parkinson's disease. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.