Increased soluble tumor necrosis factor-α receptors in patients with major depressive disorder
Increased soluble tumor necrosis factor-α receptors in patients with major depressive disorder
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DOI：
10.1111/j.1440-1819.2008.01918.x
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发表时间：
2009-01-01
影响因子：
11.9
通讯作者：
Bauer, Moises E.
中科院分区：
文献类型：
--
作者：
Grassi-Oliveira, Rodrigo;Brietzke, Elisa;Bauer, Moises E.
几条证据表明，重度抑郁症与炎症状态有关。肿瘤坏死因子-Alpha已被研究为情绪障碍的潜在分子靶点。肿瘤坏死因子-Alpha通过与称为TNFR1和TNFR2的特定细胞膜受体结合来发挥其活性。本研究的目的是研究主要抑郁症患者的可溶性等离子体TNFR1（STNFR1）和TNFR2水平（STNFR2）。与健康对照组（n = 19）进行了比较。 。评估了贝克抑郁症库存的抑郁症状严重程度；创伤后应激障碍（PTSD）症状在PTSD清单-Civilian版本上进行了评估；以及儿童时期对童年创伤问卷的虐待和忽视。血浆肿瘤坏死因子-Alpha及其可溶性受体通过ELISA测量。患者没有肿瘤坏死因子-Alpha浓度的变化，但与对照组相比，STNFR1（P <0.001）和STNFR2（P <0.001）和STNFR2（P <0.001）和STNFR2（P <0.001）没有变化。通过年龄（B = 0.25，P = 0.05）和PTSD样症状（B = 0.41，P = 0.002）和STNFR2的STNFR2通过年龄（B = 0.67，P = 0.67，P <0.001）来积极预测STNFR1的血浆水平。可溶性肿瘤坏死因子-Alpha受体可能是严重抑郁症的炎症活性的可靠标记。
Several lines of evidence suggest that major depressive disorder is associated with an inflammatory status. Tumor necrosis factor-alpha has been investigated as a potential molecular target in mood disorders. Tumor necrosis factor-alpha exerts its activity through binding to specific cell membrane receptors named as TNFR1 and TNFR2. The aim of the present study was to investigate soluble plasma TNFR1 (sTNFR1) and TNFR2 levels (sTNFR2) in major depressive disorder patients.Female outpatients with major depressive disorder (n = 30) were compared with a healthy control group (n = 19). Severity of depressive symptoms was evaluated on Beck Depression Inventory; post-traumatic stress disorder (PTSD) symptoms were evaluated on PTSD Checklist-Civilian Version; and childhood abuse and neglect on the Childhood Trauma Questionnaire. Plasma tumor necrosis factor-alpha and its soluble receptors were measured by ELISA.Patients had no changes in tumor necrosis factor-alpha concentrations but did have increased sTNFR1 (P < 0.001) and sTNFR2 (P < 0.001) levels compared to controls. Plasma level of sTNFR1 was positively predicted by age (B = 0.25, P = 0.05) and PTSD-like symptoms (B = 0.41, P = 0.002) and plasma levels of sTNFR2 by depression severity (B = 0.67, P < 0.001).Soluble tumor necrosis factor-alpha receptors could be reliable markers of inflammatory activity in major depression.