Basal fuel homoeostasis in symptomatic human immunodeficiency virus infection.
Basal fuel homoeostasis in symptomatic human immunodeficiency virus infection.
复制标题
有症状的人类免疫缺陷病毒感染中的基础燃料稳态。
作者：
M. Hommes;J. Romijn;E. Endert;J. K. E. Eeftinck Schattenkerk;H. Sauerwein
1.在8名临床稳定的症状性人类免疫缺陷病毒感染患者和7名健康对照受试者中，使用间接量热法和预充连续输注[3- 3 H]葡萄糖和[14 C]棕榈酸盐研究了葡萄糖和脂肪代谢。2.在吸收后状态（过夜禁食16小时）和过夜禁食22小时后再次进行研究。3.在吸收后状态，净脂肪氧化和三酰甘油（“甘油三酯”）浓度显着较高的患者，但浓度和营业额的游离脂肪酸患者和对照组之间没有显着差异。过夜禁食22小时后，与对照组相比，患者的游离脂肪酸周转率显著升高。4.吸收后葡萄糖氧化，葡萄糖周转率和葡萄糖清除率在患者和对照组之间没有差异。虽然禁食诱导患者的葡萄糖转换率显著下降，但患者和对照组的血糖浓度下降幅度更大。5.患者和对照组之间的胰岛素或反调节激素的血浆浓度无差异。6.它的结论是代谢适应短期饥饿在临床上稳定的人免疫缺陷病毒感染患者不同于健康对照组。短期饥饿导致葡萄糖周转率显著下降，而脂肪代谢明显受到刺激。这些变化不能用胰岛素或反调节激素浓度的差异来解释。
1. In eight clinically stable symptomatic human-immunodeficiency-virus-infected patients and in seven healthy control subjects, glucose and fat metabolism were studied, using indirect calorimetry and primed continuous infusions of [3-3H]glucose and [14C]palmitate. 2. Studies were performed in the post-absorptive state (16 h of overnight fasting) and again after 22 h of overnight fasting. 3. In the post-absorptive state, net fat oxidation and triacylglycerol ('triglyceride') concentrations were significantly higher in the patients, but concentrations and turnover of free fatty acids were not significantly different between patients and control subjects. After 22 h of overnight fasting, free fatty acid turnover in the patients rose to significantly higher levels when compared with the control subjects. 4. Post-absorptive glucose oxidation, glucose turnover and glucose clearance did not differ between patients and control subjects. Although fasting induced a significantly greater decline in glucose turnover in the patients, plasma glucose concentrations decreased comparably in patients and control subjects. 5. No differences were found in plasma concentrations of insulin or of the counter-regulatory hormones between patients and control subjects. 6. It is concluded that the metabolic adaptation to short-term starvation in clinically stable human-immuno-deficiency-virus-infected patients differs from that in healthy control subjects. Short-term starvation results in a significantly greater fall in glucose turnover, whereas fat metabolism is clearly stimulated. These alterations cannot be explained by differences in the concentrations of insulin or of the counter-regulatory hormones.