ELM-the eukaryotic linear motif resource in 2020
ELM-the eukaryotic linear motif resource in 2020
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DOI：
10.1093/nar/gkz1030
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发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Gibson, Toby J.
中科院分区：
文献类型：
--
作者：
Kumar, Manjeet;Gouw, Marc;Gibson, Toby J.
真核线性基序(ELM)资源是人工挑选的实验验证的短线性基序(SLIM)的储存库。自近20年前首次发布以来，ELM已成为分子生物界研究许多蛋白质功能区域不可或缺的资源。在这次更新中，我们增加了21个新的基序类别，对12个基序类别进行了重大修改，并增加了400个新实例，主要集中在DNA损伤、细胞骨架、SH2结合的磷酸酪氨酸基序以及致病细菌效应蛋白对基序的模拟。目前发布的ELM数据库包含289个基序类别和3523个单独的蛋白质基序实例，这些实例来自3467种科学出版物。
The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications.