Four novel withanolide-type steroids from the leaves of Solanum cilistum
Four novel withanolide-type steroids from the leaves of Solanum cilistum
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DOI：
10.1248/cpb.49.1440
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发表时间：
2001-11-01
影响因子：
1.7
通讯作者：
Nohara, T
中科院分区：
文献类型：
--
作者：
Zhu, XH;Ando, J;Nohara, T
从缘毛茄（Solanum cilistum）叶片中分离得到4个新的睡茄内酯型甾体化合物，分别命名为cilistols p，pm，p1和u（1-4）。通过光谱手段表征了相应的结构如下：ciliopropylp（1）为（22 R，24 R，25 R，26 S）-1-oxo-22，26-epoxy-3 alpha，5 alpha -eyeloergostane-6 beta，17 alpha，24，25，26-pentaol 26-O-beta -D-glucopyranoside，cilipyranopm（2）对应于1的6-O-甲基醚衍生物; cilibrillop 1（3）表示为1的24-O-甲基醚，cilibrillu（4）被证明是C-24和-25之间的环氧化物，推测通过开环携带纤毛虫p、pm和p1。
Four novel withanolide-type steroids named cilistols p, pm, p1 and u (1-4, respectively), were isolated from the leaves of Solanum cilistum. The respective structures were characterized by spectroscopic means as follows: cilistol p (1) was (22R,24R,25R,26S)-1-oxo-22,26-epoxy-3 alpha ,5 alpha -eyeloergostane-6 beta ,17 alpha, 24,25,26-pentaol 26-O-beta -D-glucopyranoside, cilistol pm (2) corresponded to the 6-O-methyl ether derivative of 1; cilistol p1 (3) was represented as the 24-O-methyl ether of 1, and cilistol u (4) was shown to be the epoxide between C-24 and -25, presumably bearing cilistols p, pm and p1 by ring-opening.