The histology of equine encephalomyelitis
The histology of equine encephalomyelitis
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DOI：
10.1084/jem.59.5.529
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发表时间：
1934-05-01
影响因子：
15.3
通讯作者：
Hurst, EW
中科院分区：
文献类型：
--
作者：
Hurst, EW
马脑脊髓炎病毒的东部株在马、牛、羊和狗中引起异常严重的脑脊髓炎，其特征是神经细胞急性原发性变性、核包涵体的出现、多形核浸润伴早期小胶质细胞增殖和血管周围浸润。大脑皮层、丘脑和下丘脑区域的病变比其他部位更明显；脑膜浸润是次要的。马匹与西方病毒株发生的类似变化不那么强烈和广泛。在小型实验动物（如豚鼠）中，东方病毒会引起急性脑脊髓炎，特别影响高级嗅觉中枢，神经细胞中出现核包涵体，神经胶质和中胚层细胞核中出现微小的嗜氧小体。这只动物还患有支气管肺炎。东方或西方病毒株在豚鼠中产生的疾病类型没有差异。
The eastern strain of the equine encephalomyelitis virus evokes in the horse, calf, sheep, and dog an unusually intense encephalomyelitis characterized by acute primary degeneration of nerve cells, the appearance of nuclear inclusions, polymorphonuclear infiltration with early microglial proliferation, and perivascular infiltration. Lesions are more marked in cerebral cortex, thalamus, and hypothalamic regions than elsewhere; meningeal infiltration is secondary. Similar changes in horses with the western strain of virus are less intense and extensive. In small laboratory animals, such as the guinea pig, the eastern virus causes an acute encephalomyelitis especially affecting the higher olfactory centers, with nuclear inclusions in nerve cells and tiny oxyphilic bodies in glial and mesodermal nuclei. In this animal there was also a bronchopneumonia. There was no difference in type of disease produced in guinea pigs by eastern or western strains of virus.