MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity
MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity
复制标题
MiR-27b-3p 对与中心性肥胖相关的人内脏脂肪褐变的调节
作者：
Yu Jing;Lv Yifan;Di Wenjuan;Liu Juan;Kong Xiaocen;Sheng Yunlu;Huang Min;Lv Shan;Qi Hanmei;Gao Mei;Liang Hui;Kim Sarah;Fu Zan;Zhou Hong;Ding Guoxian
鉴于中心性肥胖的患病率不断上升以及发现米色细胞出现在白色脂肪组织中，增强这些能量消耗脂肪细胞或白色脂肪库内的“布朗宁”的策略已成为对抗肥胖及其相关疾病的治疗兴趣。本研究旨在探讨microRNA（miRNA）-27 b-3 p在人内脏脂肪组织（VAT）布朗宁中的作用。结果随着BMI和腰臀比的升高，VAT中UCP 1的表达逐渐降低，而miR-27 b-3 p的表达与BMI和腰臀比呈正相关。miR-27 b-3 p的高表达与人内脏脂肪细胞的布朗宁能力降低相关。miR-27 b-3 p的拮抗作用导致人内脏脂肪细胞布朗宁能力的增强.ConclusionsThese findings highlight the decrease布朗宁ability of VAT from humans with obesity and the role of miR-27 b-3 p in regulating布朗宁of human visceral adipocytes.他们认为，miR-27 b-3 p应进一步探索作为治疗中心性肥胖的潜在靶点。
ObjectiveGiven the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy‐expending adipocytes or “browning” within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)‐27b‐3p in human visceral adipose tissue (VAT) browning.MethodsExpression of miR‐27b‐3p and UCP1 in VAT and serum of humans was measured. MiR‐27b‐3p was overexpressed or suppressed in human visceral stromal fraction cells to analyze the potential role of miR‐27b‐3p.ResultsUCP1 expression in human VAT decreased with elevated BMI and waist‐hip ratio, whereas expression of miR‐27b‐3p was found to correlate positively with BMI and waist‐hip ratio. High expression of miR‐27b‐3p was associated with reduced browning ability of human visceral adipocytes. Antagonism of miR‐27b‐3p led to the enhancement of browning ability in human visceral adipocytes.ConclusionsThese findings highlight the decreased browning ability of VAT from humans with obesity and the role of miR‐27b‐3p in regulating browning of human visceral adipocytes. They suggest that miR‐27b‐3p should be further explored as a potential target for the treatment of central obesity.