Neuropsychological function in Gulf War veterans: relationships to self-reported toxicant exposures.
Neuropsychological function in Gulf War veterans: relationships to self-reported toxicant exposures.
复制标题
海湾战争退伍军人的神经心理功能：与自我报告的有毒物质暴露的关系。
DOI：
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发表时间：
2001
影响因子：
3.5
通讯作者：
D. Ozonoff
中科院分区：
文献类型：
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作者：
R. F. White;S. Proctor;T. Heeren;J. Wolfe;M. Krengel;J. Vasterling;K. Lindem;K. Heaton;P. Sutker;D. Ozonoff
背景
本研究的目的是（1）探索海湾战争（GW）退伍军人的中枢神经系统（CNS）功能障碍的证据，神经心理学测试和（2）检查是否表现在神经心理学测试与特定的神经毒物暴露在海湾地区经历。
方法
使用分层随机抽样方法从两个不同的GW退伍军人队列中选择GW部署组。一个比较组，已被称为GW服务，但部署到德国，而不是海湾也进行了审查。使用预先确定的电池评估神经心理功能，选择包括测试已知是高度敏感的行为影响的神经毒物被认为是存在于海湾。
结果
自我报告的暴露与控制创伤后应激障碍、重性抑郁症和其他已知的神经心理测试表现协变量的神经心理测试表现有关。结果表明，GW部署的退伍军人比德国部署的退伍军人在几个特定的神经心理测试表现更差，但调整后的多重比较，只有情绪投诉的差异仍然显着。在全球变暖部署组，自我报告的化学战剂暴露与涉及特定功能领域的认知测试表现较差。
结论
结果提供的证据表明，有微妙的差异，中枢神经系统功能之间的GW部署的退伍军人谁报告化学战剂暴露，而在GW剧院。
BACKGROUND
The present study was aimed at (1) exploring evidence of central nervous system (CNS) dysfunction among Gulf War (GW) veterans on neuropsychological tests and (2) examining whether performance on neuropsychological tests was related to specific neurotoxicant exposures experienced in the Gulf.
METHODS
The GW-deployed groups were selected using stratified random sampling methods from two distinct cohorts of GW veterans. A comparison group that had been called up for GW service but deployed to Germany rather than the Gulf also was examined. Neuropsychological function was assessed using a pre-determined battery chosen to include tests known to be highly sensitive to the behavioral effects of the neurotoxicants thought to have been present in the Gulf.
RESULTS
Self-reported exposures were related to neuropsychological test performance controlling for post-traumatic stress disorder, major depression, and other known covariates of neuropsychological test performance. Results showed that GW-deployed veterans performed more poorly than the Germany-deployed veterans on several specific neuropsychological tests, but after adjustment for multiple comparisons, only the differences in mood complaints remained significant. Within the GW-deployed group, self-reported exposure to chemical warfare agents was associated with poorer performance on cognitive tests involving specific functional domains.
CONCLUSIONS
Results provide evidence that there are subtle differences in CNS function among GW-deployed veterans who report chemical warfare agent exposure while in the GW theater.