The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis
The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis
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DOI：
10.1016/s0925-4773(99)00272-5
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发表时间：
2000-03-01
影响因子：
2.6
通讯作者：
Duterque-Coquillaud, M
中科院分区：
文献类型：
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作者：
Vlaeminck-Guillem, V;Carrere, S;Duterque-Coquillaud, M
Erg基因属于编码一类转录因子的Ets家族。为了获得新的见解在广泛的Ets家族内的Erg基因的体内功能特异性，我们使用原位杂交，以确定其在小鼠胚胎发生的表达模式。我们发现，Erg基因的表达占主导地位的中胚层组织，包括内皮细胞，前软骨和泌尿生殖领域。一个特定的Erg基因表达也被确定在迁移的神经嵴细胞。与最密切的ERG相关基因Fli-1的比较显示，这两个基因的表达部分重叠，这表明它们可能有助于在这些组织中的相关功能。像其他Ets家族基因一样，Erg似乎参与了小鼠胚胎发生中的几个基本发育步骤，包括上皮-间充质转化、细胞迁移、定居和分化。(C)2000 Elsevier Science爱尔兰有限公司保留所有权利。
The Erg gene belongs to the Ets family encoding a class of transcription factors. To gain new insight on the in vivo functional specificity of the Erg gene within the wide Ets family, we used in situ hybridization to determine its expression pattern during murine embryogenesis. We found that the Erg gene expression predominates in mesodermal tissues, including the endothelial, precartilaginous and urogenital areas. A specific Erg gene expression was also identified in migrating neural crest cells. A comparison with Fli-1, the most closely Erg-related gene, revealed that both gene expressions partially overlap, suggesting that they may contribute to related functions in these tissues. Like other Ets family genes, Erg seems involved in several fundamental developmental steps in murine embryogenesis, including epithelio-mesenchymal transition, cell migration, settlement and differentiation. (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.