Clinical laboratory features of Meigs' syndrome: a retrospective study from 2009 to 2018
Clinical laboratory features of Meigs' syndrome: a retrospective study from 2009 to 2018
复制标题
梅格斯综合征临床实验室特征：2009-2018年回顾性研究
DOI：
10.1007/s11684-019-0732-6
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发表时间：
2020-07-10
影响因子：
8.1
通讯作者：
Wang, Fang
中科院分区：
文献类型：
--
作者：
Shang, Wenwen;Wu, Lei;Wang, Fang
梅格斯综合征(MS)是卵巢良性肿瘤的罕见并发症，易误诊为卵巢癌(OC)。我们回顾了2009-2018年间被诊断为多发性硬化症患者的临床实验室数据。MS组血清碳水化合物抗原125和HE4水平高于卵巢卵泡膜瘤纤维瘤(OTF)组和健康对照组(均P<0.05)。但MS组血清HE4水平低于OC组(P<；0.001)。血常规检查显示，MS组淋巴细胞绝对数和百分率明显低于OTF组和对照组(均P<0.05)。然而，MS组的这些变量高于OC组(P<；0.05)。MS组中性粒细胞/淋巴细胞比率(NLR)显著低于OC组(P<0.05)，而淋巴细胞/单核细胞比率明显高于OC组(P<0.05)。MS组NLR、血小板/淋巴细胞比率和全身免疫指数显著高于OTF组和对照组(均P<0.05)。MS患者术前外周血中低氧诱导因子-1mRNA水平显著高于OTF、OC和对照组，而葡萄糖转运蛋白1、乳酸脱氢酶和烯醇化酶1mRNA水平显著低于OTF患者、OC患者和对照组(均P<0.05)。MS肿瘤切除后，上述四种糖代谢基因的表达优先恢复到正常水平(P<；0.001)。这些临床实验室特征有助于提高多发性硬化的术前诊断准确性。
Meigs' syndrome (MS), a rare complication of benign ovarian tumors, is easily misdiagnosed as ovarian cancer (OC). We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018. Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma (OTF) and healthy control groups (allP< 0.05). However, the serum HE4 levels were lower in the MS group than in the OC group (P< 0.001). A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups (allP< 0.05). However, these variables were higher in the MS group than in the OC group (bothP< 0.05). The neutrophil-to-lymphocyte ratio (NLR) was also significantly lower, whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group (bothP< 0.05). The NLR, platelet-to-lymphocyte ratio, and systemic immune index were significantly higher in the MS group than in the OTF and control groups (allP< 0.05). The hypoxia-inducible factor-1 mRNA levels were also significantly higher, whereas the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4(+)T cells obtained preoperatively in a patient with MS than those in patients with OTF, patients with OC, and controls (allP< 0.05). The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS (P< 0.001). These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.