The secret marriage between calcium and tumor angiogenesis
The secret marriage between calcium and tumor angiogenesis
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DOI：
10.1177/153303460800700408
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发表时间：
2008-08-01
影响因子：
2.8
通讯作者：
Pla, Alessandra Fiorio
中科院分区：
文献类型：
--
作者：
Munaron, Luca;Tomatis, Cristiana;Pla, Alessandra Fiorio
内皮细胞的生物化学和对各种外部刺激的反应性受细胞内钙离子浓度的调节。在过去的20年里，基于荧光探针的电生理学和功能成像提供了一些关于钙离子在单细胞水平上的动力学和作用的信息：高度多样化的细胞外激动剂，如促血管生成生长因子和血管活性化合物，在生理和病理条件下，细胞内钙离子的增加和特定的信息被传递到细胞的增殖、分化、死亡、运动等过程中。显然，在多细胞和组织水平上的研究要复杂得多。在这篇综述中，我们讨论了潜在的特定作用的钙信号在肿瘤血管生成的进展，试图解决两个关键问题：（一）这个离子如何发挥特定的作用，在血管生成的调节;和（ii）它可以被用作一个目标，以干扰或防止肿瘤血管生成？
Endothelial cell biochemistry and responsiveness to a wide variety of external stimula are regulated by intracellular calcium concentration.During the last twenty years, electrophysiology and functional imaging based on the use of fluorescent probes provided several informations about the dynamics and role of calcium at the single cell level: highly diverse extracellular agonists, such as proangiogenic growth factors and vasoactive compounds, trigger increases in intracellular calcium and specific informations are transduced for proliferation, differentiation, death, movement in physiological and pathological conditions.Obviously, the investigation at multicellular and tissutal levels is much more complex. In this review we discuss the potential specific roles of calcium signaling in tumor angiogenesis progression trying to address two key questions: (i) how can this ion play specific roles in the angiogenesis regulation; and (ii) could it be used as a target to interfere with or prevent tumor vascularization?