REGIONAL VAGOSYMPATHETIC CONTROL OF HEART
REGIONAL VAGOSYMPATHETIC CONTROL OF HEART
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DOI：
10.1152/ajplegacy.1974.227.2.444
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发表时间：
1974-01-01
影响因子：
--
通讯作者：
ARMOUR, JA
中科院分区：
文献类型：
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作者：
RANDALL, WC;ARMOUR, JA
方法选取22只麻醉开胸犬（盐酸苯环利定2.0 ng/kg， α -氯氯蔗糖60 ~ 80 rug/kg）进行实验。将Walton-Brodie应变弓在中等张力下分别缝合于右心房（RA）和左心房（LA）、右心室锥体（RVC）、右心室窦（RVS）、左心室基底（LVB）和左心室外侧面（LVL）等6个心房段。同时记录股动脉血压（BP）和心电图（ECG）导联。所有的录音都是在一个8通道模型R Dynograph上完成的。方波刺激脉冲来自S4 Grass型刺激器，刺激参数为低至40 Hz，持续时间为2-5英寸，强度为4-8 V。40 Hz、2 ins和4 V是迷走神经传出纤维兴奋的轴上参数，也是迷走神经传入纤维兴奋的合适参数。在上肺静脉与颈尾神经节之间的一个点之间的五个不同水平上仔细地从纵隔胸膜上解剖胸迷走神经（图1）。这些水平包括剥离：/Q紧接在右侧的奇静脉和左侧的上肺静脉下方；B)紧靠右侧奇静脉上方，左侧肺动脉主动脉水平；C)大约在右边的奇静脉和锁骨下静脉的中间在左边的迷走神经的喉返神经分支的正下方；D)即刻下，E)即刻上附于两侧颈尾神经节。颈部下颈区的六分之一(F) 1为
METHODSExperirnents were carried out in 22 anesthetized(phencyclidine hydrochloride, 2.0 rng/kg, and alpha chloralose, 60-80 rug/kg), open-chest dogs. Walton-Brodie straingauge arches were sutured under moderate tension to each of six rnyocardial segments including right (RA) and left (LA) atria, right ventricular conus (RVC), right ventricular sinus (RVS), left ventricular base (LVB), and left ventricular lateral surface (LVL). Femoral arterial blood pressure (BP) and lead II of the electrocardiogram(ECG) were also recorded. All recordings were made on an eight-channel model R Dynograph. Square-wave stimulation pulses were delivered from a model S4 Grass stiinulator with stimulation parameters of lo-40 Hz, 2-5 ins duration, and 4-8 V intensity. Parameters of 40 Hz, 2 ins, and 4 V were found to be suprainaxiinal for excitation of vagal efferent fibers and appropriate for the afferent fibers contained within the vagus. The thoracic vagus was carefully dissected from the mediastinal pleura at each of five different levels between the level of the superior pulmonary vein to a point immediately rostra1 to the caudal cervical ganglion (Fig. 1). These levels included dissection:/Q immediately inferior to the azygous vein on the right and the superior pulmonary vein on the left; B) imnediately above the azygous vein on the right and at the level of the main pulmonary artery on the left; C) approximately midway between the azygous and the subclavian vein on the right and immediately inferior to the branching of the recurrent laryngeal nerve from the vagus on the left; D) ilnrnediately inferior, and E) irmnediately rostra1 to the caudal cervical ganglion on both sides. A sixth (F) 1 eve1 in the rnidcervical region of the neck was