Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
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DOI：
10.1016/j.biopsych.2004.10.012
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发表时间：
2005-01-15
影响因子：
10.6
通讯作者：
Lesch, KP
中科院分区：
文献类型：
--
作者：
Newman, TK;Syagailo, YV;Lesch, KP
背景资料：单胺氧化酶A（MAOA）基因的等位基因变异与人类早期不良经历相关的行为障碍和反社会、攻击性行为有关。我们测试的假设，在恒河猴MAOA基因启动子区的重复多态性影响男性subjects.Methods：45个无关的男性猴子提出或没有他们的母亲进行了测试的竞争和社会群体的侵略行为。MAOA基因启动子多态性的功能活性进行了测定和基因型得分评估遗传和环境对aggression.Results的影响：恒河猴的MAOA基因的转录是由一个orthopathic多态性（rhMAOA-LPR）在其上游调控区调制。高和低活性等位基因的rhMAOA-LPR表现出基因型X环境相互作用的侵略行为，这样，母亲饲养的雄性猴子与低活性相关的等位基因有较高的侵略scores.Conclusions：这些结果表明，在MAOA活性的等位基因变异的行为表达是敏感的社会经验早期发展，其功能的结果可能取决于社会背景。
Background: Allelic variation of the monoamine oxidase A (MAOA) gene has been implicated in conduct disorder and antisocial, aggressive behavior in humans when associated with early adverse experiences. We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects.Methods: Forty-five unrelated male monkeys raised with or without their mothers were tested for competitive and social group aggression. Functional activity of the MAOA gene promoter polymorphism was determined and genotypes scored for assessing genetic and environmental influences on aggression.Results: Transcription of the MAOA gene in rhesus monkeys is modulated by an orthologous polymorphism (rhMAOA-LPR) in its upstream regulatory region. High- and low-activity alleles of the rhMAOA-LPR show a genotype X environment interaction of aggressive behavior, such that mother reared male monkeys with the low-activity-associated allele had higher aggression scores.Conclusions: These results suggest that the behavioral expression of allelic variation in MAOA activity is sensitive to social experiences early in development and that its functional outcome might depend on social context.