Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.
Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.
复制标题
皮层和皮层下听觉功能 MRI 的连续采样与主动噪声消除和稀疏采样的比较。
DOI：
10.1002/mrm.28902
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发表时间：
2021
影响因子：
3.3
通讯作者：
Dewey RS
中科院分区：
文献类型：
--
作者：
Dewey RS
目的：使用功能性MRI检测声音相关活动需要听觉刺激比强烈的背景扫描声噪声更显著。各种策略可以减少扫描仪噪声的影响，包括“稀疏”时间采样，单/聚类采集提供没有任何背景扫描仪噪声的间隔，或在“连续”时间采样期间主动降噪（ANC），这产生了一个声信号，增加了扫描仪噪声的破坏性，大大降低了参与者耳膜处的声能量。此外，多波段功能性MRI允许同时收集多个切片，从而在给定的采样周期内减少扫描仪噪声。方法对15名听力正常的受试者进行各向同性多波段功能MRI （1.5 mm）稀疏采样（有效TR = 9000 ms，采集持续时间= 1962 ms）和连续采样（TR = 2000 ms）的比较。持续宽带噪声刺激可同时激活皮层下和皮层听觉区域内的持续和短暂听觉反应。结果在整个听觉通路中检测到强大的宽带噪声相关活动。研究发现，与稀疏采样相比，使用ANC进行连续采样在检测瞬时（开始）刺激反应方面具有统计学上显著的优势，特别是在听觉皮层（P< 0.001）和下丘（P< 0.001），而在检测偏移和持续反应方面，稀疏采样比连续ANC提供的优势微不足道（在上榄复合体、下丘、内侧弯曲体和听觉皮层中P ~ 0.05）。结论稀疏和连续的ANC多波段功能MRI方案在观察瞬时（开始和抵消）和持续刺激反应方面具有不同的优势。
PurposeDetecting sound‐related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse” temporal sampling with single/clustered acquisitions providing intervals without any background scanner acoustic noise, or active noise cancelation (ANC) during “continuous” temporal sampling, which generates an acoustic signal that adds destructively to the scanner acoustic noise, substantially reducing the acoustic energy at the participant’s eardrum. Furthermore, multiband functional MRI allows multiple slices to be collected simultaneously, thereby reducing scanner acoustic noise in a given sampling period.MethodsIsotropic multiband functional MRI (1.5 mm) with sparse sampling (effective TR = 9000 ms, acquisition duration = 1962 ms) and continuous sampling (TR = 2000 ms) with ANC were compared in 15 normally hearing participants. A sustained broadband noise stimulus was presented to drive activation of both sustained and transient auditory responses within subcortical and cortical auditory regions.ResultsRobust broadband noise‐related activity was detected throughout the auditory pathways. Continuous sampling with ANC was found to give a statistically significant advantage over sparse sampling for the detection of the transient (onset) stimulus responses, particularly in the auditory cortex (P< .001) and inferior colliculus (P< .001), whereas gains provided by sparse over continuous ANC for detecting offset and sustained responses were marginal (p~ 0.05 in superior olivary complex, inferior colliculus, medial geniculate body, and auditory cortex).ConclusionsSparse and continuous ANC multiband functional MRI protocols provide differing advantages for observing the transient (onset and offset) and sustained stimulus responses.