Amplitude of low-frequency oscillations in Parkinson's disease: a 2-year longitudinal resting-state functional magnetic resonance imaging study.
Amplitude of low-frequency oscillations in Parkinson's disease: a 2-year longitudinal resting-state functional magnetic resonance imaging study.
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DOI：
10.4103/0366-6999.151652
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发表时间：
2015-03-05
影响因子：
6.1
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Hu XF;Zhang JQ;Jiang XM;Zhou CY;Wei LQ;Yin XT;Li J;Zhang YL;Wang J
神经影像学研究发现帕金森病（PD）患者存在功能变化。然而，大多数针对 PD 患者的功能磁共振成像 (fMRI) 研究都是与任务相关的和横断面的。本研究使用静息态功能磁共振成像研究了 PD 患者在基线和 2 年后观察到的功能变化。进一步探讨PD患者全脑自发神经活动与其临床特征的关系。 17 名 PD 患者在基线和 2 年后使用源自相同 3T MRI 的静息态 fMRI 进行了 MRI 手术。此外，还使用静息态功能磁共振成像对 20 名年龄和性别匹配的健康对照进行了检查。低频波动分数幅度（fALFF）方法用于分析功能磁共振成像数据。非线性配准用于模拟扫描间隔内受试者内部的变化，以及 PD 患者和健康对照之间的变化。在显示 fALFF 差异的区域进行 fALFF 值与临床特征之间的相关分析。与对照组相比，PD患者的左侧颞下回、右侧顶下小叶（IPL）和右侧额中回的fALFF值升高。随访2年，与基线相比，PD患者右侧颞中回、右侧枕中回fALFF值升高，右侧小脑、右侧丘脑、右侧纹状体、左侧顶上小叶、左侧IPL、左侧中央前回、左侧中央后回fALFF值降低（AlphaSim校正后，P < 0.01）。此外，右侧小脑的fALFF值与统一PD评定量表（UPDRS）运动评分（r = 0.51，P < 0.05，未校正）和UPDRS运动评分的变化（r = 0.61，P < 0.05，未校正）呈正相关。我们研究中 fALFF 值的基线和纵向变化表明，随着疾病的进展，大脑功能障碍可能会影响与皮质-纹状体-苍白球-丘脑环路和小脑-丘脑-皮质环路相关的区域，并且小脑自发神经活动的改变也可能在 PD 患者的疾病进展中发挥重要作用。
Neuroimaging studies have found that functional changes exist in patients with Parkinson's disease (PD). However, the majority of functional magnetic resonance imaging (fMRI) studies in patients with PD are task-related and cross-sectional. This study investigated the functional changes observed in patients with PD, at both baseline and after 2 years, using resting-state fMRI. It further investigated the relationship between whole-brain spontaneous neural activity of patients with PD and their clinical characteristics. Seventeen patients with PD underwent an MRI procedure at both baseline and after 2 years using resting-state fMRI that was derived from the same 3T MRI. In addition, 20 age- and sex-matched, healthy controls were examined using resting-state fMRI. The fractional amplitude of low-frequency fluctuation (fALFF) approach was used to analyze the fMRI data. Nonlinear registration was used to model within-subject changes over the scanning interval, as well as changes between the patients with PD and the healthy controls. A correlative analysis between the fALFF values and clinical characteristics was performed in the regions showing fALFF differences. Compared to the control subjects, the patients with PD showed increased fALFF values in the left inferior temporal gyrus, right inferior parietal lobule (IPL) and right middle frontal gyrus. Compared to the baseline in the 2 years follow-up, the patients with PD presented with increased fALFF values in the right middle temporal gyrus and right middle occipital gyrus while also having decreased fALFF values in the right cerebellum, right thalamus, right striatum, left superior parietal lobule, left IPL, left precentral gyrus, and left postcentral gyrus (P < 0.01, after correction with AlphaSim). In addition, the fALFF values in the right cerebellum were positively correlated with the Unified PD Rating Scale (UPDRS) motor scores (r = 0.51, P < 0.05, uncorrected) and the change in the UPDRS motor score (r = 0.61, P < 0.05, uncorrected). The baseline and longitudinal changes of the fALFF values in our study suggest that dysfunction in the brain may affect the regions related to cortico-striato-pallido-thalamic loops and cerebello-thalamo-cortical loops as the disease progresses and that alterations to the spontaneous neural activity of the cerebellum may also play an important role in the disease's progression in patients with PD.