Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands
Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands
复制标题
DOI：
10.1007/s11096-006-9061-3
复制
发表时间：
2007-04-01
影响因子：
--
通讯作者：
Stricker, Bruno H. Ch.
中科院分区：
文献类型：
--
作者：
Becker, Matthijs L.;Caspers, Peter W. J.;Stricker, Bruno H. Ch.
目的：存在多种药物相互作用（D-DI），其中一些可能会导致严重的不良患者结局。当风险高于收益时，应避免分配相互作用的药物组合。本研究的目的是确定荷兰社区药房配发不良相互作用药物组合的决定因素。方法：根据 2001 年 1 月 1 日至 2002 年 10 月 31 日期间配发 11 种不良相互作用药物组合的情况，总共选择了 256 家荷兰社区药房。卫生保健监察局 (IHC) 向这些药房发送了一份关于其流程和情况的调查问卷。结构特征。主要结果指标：11种不良相互作用药物组合的分配次数。结果：完成了246份调查问卷（答复率96.1%）。仅发现大环内酯类抗生素和地高辛之间的 D-DI 的分配决定因素，而未发现其他 10 种 D-DI 的分配决定因素。使用不同药物监测系统的药房在配发这种相互作用的药物组合方面存在差异，并且属于医疗保健中心的药房更频繁地配发这种相互作用的药物组合。结论：荷兰社区药房的药物监测似乎是有效的。尽管对于大多数 D-DI 没有发现决定因素，但工艺和结构特征可能会对不良相互作用药物组合的分配产生影响。
Objective: There are many drug-drug interactions (D-DI) of which some may cause severe adverse patient outcomes. Dispensing interacting drug combinations should be avoided when the risks are higher than the benefits. The objective of this study was to identify determinants of dispensing undesirable interacting drug combinations by community pharmacies in the Netherlands.Methods: A total of 256 Dutch community pharmacies were selected, based on the dispensing of 11 undesirable interacting drug combinations between January 1st, 2001 and October 31st, 2002. These pharmacies were sent a questionnaire by the Inspectorate for Health Care (IHC) concerning their process and structure characteristics.Main outcome measure: The number of times the 11 undesirable interacting drug combinations were dispensed.Results: Two hundred and forty-six questionnaires (response rate 96.1%) were completed. Dispensing determinants were only found for the D-DI between macrolide antibiotics and digoxin but not for the other 10 D-DIs. Pharmacies using different medication surveillance systems differed in the dispensing of this interacting drug combination, and pharmacies, which were part of a health care centre dispensed this interacting drug combination more often.Conclusion: Medication surveillance in Dutch community pharmacies seems to be effective. Although for most D-DIs no determinants were found, process and structure characteristics may have consequences for the dispensing of undesirable interacting drug combinations.