Association study of dopamine transporter gene (DAT1) variable tandem repeat sequence (VNTR) with obsessive-compulsive disorder in Chinese Han Population
Association study of dopamine transporter gene (DAT1) variable tandem repeat sequence (VNTR) with obsessive-compulsive disorder in Chinese Han Population
复制标题
中国汉族人群多巴胺转运蛋白基因（DAT1）可变串联重复序列（VNTR）与强迫症的关联研究
DOI：
10.1002/da.22394
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发表时间：
2015
影响因子：
0.1
通讯作者：
Liu Shiguo
中科院分区：
文献类型：
--
作者：
Zhang Shaoyan;Jiang Weihua;Tang Xiuming;Xu Quanchen;Wang Jingli;Gui Rui;Zhang Xinhua;Liu Shiguo
少突胶质细胞转录因子2(OLIG2)主要集中在脑和脊髓脑室区，在那里该蛋白刺激少突胶质细胞和特定神经元，决定运动神经元和少突胶质细胞的分化，并维持早期发育的复制。最近的研究表明，OLIG2基因与精神分裂症、心境障碍和强迫症等精神障碍有关。方法通过对400例强迫症和400例强迫症患者的OLIG2基因序列中的rs762178、rs1059004和rs9653711三个单核苷酸多态(SNPs)的分析，探讨OLIG2基因是否与中国汉族人的强迫症相关。第一，rs762178 SNP与强迫症、女性强迫症、早发型强迫症相关，rs1059004与强迫症、早发型强迫症相关，rs9653711也与强迫症、早发型强迫症相关。其次，rs762178和rs1059004、rs1059004和rs9653711、rs762178和rs9653711存在连锁不平衡。结论本研究首次在中国汉族人群中验证了OLIG2基因rs762178、rs1059004和rs9653711与强迫症的相关性。因此，在未来的研究中，OLIG2可能成为强迫症治疗的潜在靶点。进一步的研究应该证实目前的发现。
BackgroundOligodendrocyte transcription factor 2 (OLIG2) is primarily concentrated in the brain and spinal cord ventricular zone, where this protein stimulates oligodendrocytes and specific neurons, determines motor neuron and oligodendrocyte differentiation, and sustains replication in early development. Recent studies have demonstrated thatOLIG2gene is associated with mental disorders, such as schizophrenia, mood disorder, and obsessive–compulsive disorder (OCD).MethodsThe aim of the present study was to explore whetherOLIG2gene is associated with OCD in a Chinese Han population through the assessment and analysis of three single nucleotide polymorphisms (SNPs), namely, rs762178, rs1059004, and rs9653711, selected fromOLIG2gene sequences from 400 OCD samples and 459 healthy controls in a case‐controlled association study.ResultsWe demonstrated three principal results. First, SNP rs762178 was associated with OCD, female OCD, and early‐onset OCD; rs1059004 was associated with OCD and early‐onset OCD; and rs9653711 was also associated with OCD and early‐onset OCD. Second, the pairs of loci rs762178 and rs1059004, rs1059004 and rs9653711, and rs762178 and rs9653711 exhibited linkage disequilibrium. Third, the three‐locus A‐C‐G haplotype was associated with early‐onset OCD.ConclusionsThe present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of theOLIG2gene with OCD in a Chinese Han population. Thus,OLIG2might serve as a potential target for OCD treatment in future studies. Further studies should verify the current findings.