Pulmonary alveolus formation: critical period, retinoid regulation and plasticity.
Pulmonary alveolus formation: critical period, retinoid regulation and plasticity.
复制标题
肺泡形成：关键期、类维生素A调节和可塑性。
DOI：
10.1002/0470868678.ch14
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发表时间：
2001
影响因子：
--
通讯作者：
Massaro,GD
中科院分区：
文献类型：
--
作者：
Massaro,D;Massaro,GD
肺泡是肺的气体交换结构，部分是由构成未成熟肺的气体交换区域的球囊细分(分隔)形成的。虽然对间隔的调节知之甚少，但最近的研究表明：(1)全反式维甲酸(RA)治疗新生大鼠可增加间隔，并阻止由地塞米松(一种糖皮质激素)治疗的新生大鼠产生的间隔抑制；(2)对患有弹力酶诱导的肺气肿的成年大鼠，用维甲酸治疗可部分挽救失败的间隔；(3)在皮肤紧密的小鼠中，这种方法具有遗传的间隔失败的特点，并且对于以前用地塞米松治疗可预防间隔的大鼠，RA可部分挽救失败的间隔。这些发现增加了RA治疗将在患有肺气肿的人类中诱导肺泡形成的可能性。
Pulmonary alveoli, the lung's gas‐exchange structures, are formed in part by subdivision (septation) of the saccules that constitute the gas‐exchange region of the immature lung. Although little is known about the regulation of septation, relatively recent studies show: (1) all‐transretinoic acid (RA) treatment of newborn rats increases septation and prevents the inhibition of septation produced by treatment of newborn rats with dexamethasone, a glucocorticosteroid hormone; (2) treatment with RA of adult rats that have elastase‐induced emphysema increases lung elastic recoil, induces the formation of alveoli, and increases volume‐corrected alveolar surface area; and (3) in tight‐skin mice, which have a genetic failure of septation, and in rats in which septation had previously been prevented by treatment with dexamethasone, treatment with RA partially rescues the failed septation. These findings raise the possibility that treatment with RA will induce the formation of alveoli in humans with pulmonary emphysema.