CFTR and bicarbonate secretion to epithelial cells
CFTR and bicarbonate secretion to epithelial cells
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DOI：
10.1152/nips.01412.2002
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发表时间：
2003-02-01
期刊：
影响因子：
--
通讯作者：
Bridges, RJ
中科院分区：
文献类型：
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作者：
Hug, MJ;Tamada, T;Bridges, RJ
HCO3-和液体分泌缺陷是囊性纤维化患者胰腺病理生理学的标志。最近，在大多数已知表达囊性纤维化跨膜传导调节因子（CFTR）的组织中，HCO3-分泌受损。新的研究结果表明，CFTR在HCO3-的跨细胞分泌中起重要作用。
Defective HCO3- and fluid secretion are hallmarks of the pathophysiology of the pancreas of cystic fibrosis patients. Recently, impaired HCO3- secretion has been shown in most tissues known to express the cystic fibrosis transmembrane conductance regulator (CFTR). New results suggest that CFTR plays an important role in the transcellular secretion of HCO3-.