Deposition of Dry Powder Generated by Solovent in Sophia Anatomical Infant Nose-Throat (SAINT) Model
Deposition of Dry Powder Generated by Solovent in Sophia Anatomical Infant Nose-Throat (SAINT) Model
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DOI：
10.1080/02786826.2011.643257
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发表时间：
2012-01-01
影响因子：
5.2
通讯作者：
Powell, Kenneth
中科院分区：
文献类型：
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作者：
Laube, Beth L.;Sharpless, Gail;Powell, Kenneth
目的：量化9个月大的Sophia Anatomical Infant Nose-Throat（SAINT）模型中（99 m）锝标记粉末的沉积。研究方法：在30秒的潮气量（TV）呼吸期间，通过Solovent（BD Technologies）（一种具有喷雾器的活性干粉吸入器）产生粉末。通过模型的活性被捕获在过滤器上，并代表可用于沉积在肺中的粉末。鼻腔内、滤器上和垫片中的沉积物表示为垫片中注射剂量的百分比。结果：在50、100和200 mL TV下，平均（+/- SD）注射剂量分别为89.5 +/-0.09%、90.3 +/-0.11%和91.3 +/- 0.05%。从50 mL到100 mL和200 mL TV，平均鼻沉积显著增加，分别为0.60 +/-0.002%、1.72 +/-0.007%和6.75 +/-07.21%（所有p
Purpose: To quantify deposition of (99m)technetium-labeled powder in the Sophia Anatomical Infant Nose-Throat (SAINT) model of a 9-month old. Methods: Powder was generated by the Solovent (BD Technologies), an active dry powder inhaler with spacer, during 30 seconds of tidal volume (TV) breathing. Activity that passed through the model was captured on a filter and represented powder that was available for deposition in the lungs. Deposition in the nasal cavity, on the filter, and in the spacer was expressed as a percentage of the injected dose into the spacer. Results: Mean (+/- SD) injected dose averaged 89.5 +/- 0.09%, 90.3 +/- 0.11%, and 91.3 +/- 0.05% at 50, 100, and 200 mL TV, respectively. Mean nasal deposition increased significantly from 50 mL to 100 mL and 200 mL TV with 0.60 +/- 0.002%, 1.72 +/- 0.007%, and 6.75 +/- 07.21%, respectively (all p