Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study.
Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study.
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女性大肠癌与生殖和激素因素的关系：病例对照研究。
DOI：
10.1093/jnci/71.4.703
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. Mcmichael
中科院分区：
文献类型：
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作者：
J. Potter;A. Mcmichael
一项以社区为基础的病例对照研究生殖因素对澳大利亚大肠癌风险的影响。该研究涉及155例病例（99例结肠癌，56例直肠癌）和311例对照，他们接受了关于妊娠及其结局，哺乳，月经史和口服避孕药（OC）使用的采访。产次增加与结肠癌风险降低相关;第0段，相对危险度（RR）=1;第1-2段，RR=0.9，95%置信区间（CI）=0.4-1.8;第3段，RR=0.4，95% CI=0.2-0.8;首次活产年龄（AFLB）越大，（AFLB ≤ 21岁，RR=1; 22-25岁，RR=2.3，95% CI=1.0-5.5; ≥ 26岁，RR=2.7，95% CI=1.2-6.2）。这些效应是相互独立的。产次似乎对右半结肠癌的风险发挥了主要作用。OC使用在对照组中比病例组更常见（RR=0.5; 95%CI =0.3-1.2，对于曾经使用者与从未使用者），并在多项logistic分析中显示出剂量反应效应。直肠癌的点估计RR模式与结肠癌的点估计RR模式基本一致，但与1.0无显著差异。
A community-based case-control study of the effect of reproductive factors on risk of large bowel cancer in Australia is described. The study involved 155 cases (99 colon cancer, 56 rectal cancer) and 311 controls who were interviewed with regard to pregnancies and their outcomes, lactation, menstrual history, and oral contraceptive (OC) use. Increasing parity was associated with a decreasing risk of colon cancer; para 0, relative risk (RR)=1; para 1-2, RR=0.9, 95% confidence interval (CI)=0.4-1.8; para greater than or equal to 3, RR=0.4, 95% CI=0.2-0.8; later age at first live birth (AFLB) was associated with increasing risk (AFLB less than or equal to 21 yr, RR=1; 22-25 yr, RR=2.3, 95% CI=1.0-5.5; greater than or equal to 26 yr, RR=2.7, 95% CI=1.2-6.2). These effects were independent of each other. Parity appeared to exert its predominant effect on risk of cancer of the right colon. OC use was more common among controls than cases (RR=0.5; 95% CI=0.3-1.2 for ever vs. never users) and showed a dose-response effect in multiple logistic analysis. The pattern of point-estimate RR for rectal cancer was largely congruent with those for colon cancer but was not significantly different from 1.0.