A correlation study of organochlorine levels in serum, breast adipose tissue, and gluteal adipose tissue among breast cancer cases in India
A correlation study of organochlorine levels in serum, breast adipose tissue, and gluteal adipose tissue among breast cancer cases in India
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DOI：
10.1158/1055-9965.epi-04-0356
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发表时间：
2005-05-01
影响因子：
3.8
通讯作者：
Barisi, D
中科院分区：
文献类型：
--
作者：
Rusiecki, JA;Matthews, A;Barisi, D
我们使用的数据进行了乳腺癌试点研究，在印度的喀拉拉邦在1997年，其中有机氯水平进行了测量，在三个生物媒体，血清，乳腺脂肪组织，臀部脂肪组织，37例空腹乳腺癌病例（治疗前）。我们的目的是调查有机氯在不同的生物介质中的浓度之间的关系。气液色谱法测定了血清、乳房脂肪和臀部脂肪组织中二氯二苯基三氯乙烷、二氯二苯基二氯乙烷、β-苯六氯乙烷和多氯联苯同系物PCB-153和PCB-180的含量。绘制相关图，并计算乳房脂肪组织与血清、臀部脂肪组织与血清和乳房脂肪组织与臀部脂肪组织的斯皮尔曼相关系数W。我们还检查了所有汇总统计量的配对比率。对于大多数分析的有机氯，血清、乳房脂肪组织和臀部脂肪组织浓度之间存在很强的相关性，但臀部与血清中PCB-153的相关性除外。所有其他比较的相关性范围为r = 0.65至0.94。在大多数有机氯农药比较中，血清（纳克/克）与脂肪的比率接近1：1，并且在汇总统计中没有变化。据我们所知，这是第一项研究，使用三种不同的媒体从空腹科目，并全面调查有机氯农药和多氯联苯在三种媒体测量之间的关系。这些数据表明，血清与脂肪组织一样，反映了目前人体内一系列有机氯的含量，这些数据支持了这样一种观点，即可以收集血清代替脂肪组织，以获得类似的信息。然而，这种测量是最近接触和过去接触的组合，这些接触代谢缓慢，可能仍然存在。因此，研究人员在指定终生身体负担水平时应谨慎。
We used data from a breast cancer pilot study carried out in Kerala, India in 1997, for which organochlorine levels were measured in three biological media, blood serum, breast adipose tissue, and gluteal adipose tissue, of 37 fasting breast cancer cases (pretreatment). Our objective was to investigate the relationships between organochlorine concentrations in different biological media. Gas-liquid chromatography determined serum, breast adipose, and gluteal adipose tissue levels of dichlorodiphenyltricholorethane, dichlorodiphenyldichloroethane, β-benzene hexachloride, and polychlorinated biphenyl (PCB) congeners, PCB-153 and PCB-180. Correlation plots were made and Spearman correlation coefficients W calculated for breast adipose tissue versus serum, gluteal adipose tissue versus serum, and breast adipose versus gluteal adipose tissue. We also examined paired ratios of all summary statistics. There were strong correlations among serum, breast adipose tissue, and gluteal adipose tissue concentrations for most organochlorines analyzed, one exception being gluteal versus serum for PCB-153. The correlations for all other comparisons ranged from r = 0.65 to 0.94. Serum (ng/g) versus adipose ratios approached 1:1 for most of the organochlorine pesticide comparisons and did not vary by summary statistic. To our knowledge, this is the first study to use three different media from fasting subjects and to comprehensively investigate the relationship between organochlorines measured across the three media for both organochlorine pesticides and PCBs. These data indicate that blood serum reflects the present body burden of a range of organochlorines to the same extent as adipose tissue, and they support the view that serum may be collected in lieu of adipose tissue to obtain similar information. However, such measurements are a combination of both recent exposures and past exposures, which have metabolized slowly and may still persist. Therefore, investigators should use caution when assigning a level as lifetime body burden.