Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex
Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex
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DOI：
10.1152/jn.00553.2005
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发表时间：
2005-12-01
影响因子：
2.5
通讯作者：
Feldman, DE
中科院分区：
文献类型：
--
作者：
Foeller, E;Celikel, T;Feldman, DE
抑制在感觉皮层地图可塑性中的作用还不清楚。在这里，我们测试是否抑制有助于在发育中的大鼠体感（S1）皮层的感受野可塑性的表达。在正常大鼠中，gabazine（SR 95531）（一种竞争性γ-氨基丁酸（GABA）- A受体拮抗剂）的微离子电渗疗法，相对于主要的触须反应，优先解除周围触须反应，表明GABA（A）抑制通常起着使触须调谐变尖的作用.可塑性诱导短暂剥夺青春期大鼠的所有，但一个胡须，这会导致层2/ 3（L2/ 3）感受野转移远离剥夺的主要胡须，并朝着备用的周围胡须。与对照组不同，在感受野移位的单位中，gabazine优先解除对剥夺的主须的反应，这表明GABA（A）抑制相对于备用须反应优先抑制这些反应。没有观察到这种效果的L2/ 3单位，不表达感受野可塑性或在层4，感受野可塑性没有发生。因此，GABA（A）抑制通过帮助锐化备用输入周围的感受野来促进感觉地图可塑性的表达。
The role of inhibition in sensory cortical map plasticity is not well understood. Here we tested whether inhibition contributes to expression of receptive field plasticity in developing rat somatosensory ( S1) cortex. In normal rats, microiontophoresis of gabazine ( SR 95531), a competitive gamma- aminobutyric acid ( GABA)- A receptor antagonist, preferentially disinhibited surround whisker responses relative to principal whisker responses, indicating that GABA(A) inhibition normally acts to sharpen whisker tuning. Plasticity was induced by transiently depriving adolescent rats of all but one whisker; this causes layer 2/ 3 ( L2/ 3) receptive fields to shift away from the deprived principal whisker and toward the spared surround whisker. In units with shifted receptive fields, gabazine preferentially disinhibited responses to the deprived principal whisker, unlike in controls, suggesting that GABA(A) inhibition was acting to preferentially suppress these responses relative to spared whisker responses. This effect was not observed for L2/ 3 units that did not express receptive field plasticity or in layer 4, where receptive field plasticity did not occur. Thus GABA(A) inhibition promoted expression of sensory map plasticity by helping to sharpen receptive fields around the spared input.