The clinical expression and emergence of porcine circovirus 2
The clinical expression and emergence of porcine circovirus 2
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DOI：
10.1016/j.vetmic.2003.10.013
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发表时间：
2004-02-04
影响因子：
3.3
通讯作者：
Harding, JCS
中科院分区：
文献类型：
--
作者：
Harding, JCS
自从1995年在加拿大西部发现和表征以来，断奶后多系统衰竭综合征（PMWS）的分布已经增长，并且该综合征无疑是世界范围内公认的。最近，人们对几种潜在相关疾病的兴趣增加，包括猪皮炎和肾病综合征（PDNS）、增殖性和坏死性肺炎（PNP）、先天性震颤（CT-AII）、围产期心肌炎和生殖衰竭。尽管猪圆环病毒2型（PCV 2）的因果关系最近已得到证实[Vet. Pathol. 37（2000）254; J. Comp. Pathol. 122（2000）9; J. Vet. Diagn. Invest. 13（2001）185]，PCV 2存在于患病和健康猪群体中。此外，最近的血清学研究表明，在PMWS临床和非临床畜群之间，PCV 2特异性IgG滴度没有显著差异（Harding et al.，印刷中）。显然，对传播、流行病学和触发临床表达的因素知之甚少。考虑到这些不确定性，本文的目的是审查的临床表现和出现PMWS和潜在的相关疾病综合征，包括PDNS。(C)2003 Elsevier B. V.保留所有权利。
Since its discovery and characterization in western Canada in 1995, the distribution of post-weaning multisystemic wasting syndrome (PMWS) has grown and the syndrome is undoubtedly recognized worldwide. More recently, there is a heightened interest in several potentially related conditions including porcine dermatitis and nephropathy syndrome (PDNS), proliferative and necrotizing pneumonia (PNP), congenital tremors (CT-AII), perinatal myocarditis and reproductive failure. Although the causality of porcine circovirus type 2 (PCV2) has recently been proven [Vet. Pathol. 37 (2000) 254; J. Comp. Pathol. 122 (2000) 9; J. Vet. Diagn. Invest. 13 (2001) 185], PCV2 is present in both diseased and healthy pig populations. Furthermore, recent serologic studies have shown that there are no significant differences in PCV2 specific IgG titres between PMWS clinical and non-clinical herds (Harding et al., in press). Clearly, the transmission, epidemiology, and factors triggering clinical expression are poorly understood. With these uncertainties in mind, the objective of this paper is to review the clinical expression and emergence of PMWS and the potentially associated disease syndromes including PDNS. (C) 2003 Elsevier B.V. All rights reserved.