MODULATION OF FELINE ESOPHAGEAL CONTRACTIONS BY BOLUS VOLUME AND OUTFLOW OBSTRUCTION
MODULATION OF FELINE ESOPHAGEAL CONTRACTIONS BY BOLUS VOLUME AND OUTFLOW OBSTRUCTION
复制标题
DOI：
10.1152/ajpgi.1990.258.2.g208
复制
发表时间：
1990-02-01
影响因子：
--
通讯作者：
SLUSS, J
中科院分区：
文献类型：
--
作者：
MITTAL, RK;REN, JL;SLUSS, J
采用同步视频透视和测压技术，研究了给药量和食道阻塞对猫食管蠕动的影响。在食管远端植入一个特殊设计的压力袖带以控制流出物阻塞的程度。在袖口压力分别为0、20、40和60 mmHg的情况下，分别注射3、6和9 ml的体积，诱发继发性食管肠壁。流出阻塞的增加降低了蠕动的速度。低剂量时，食管收缩幅度随流出道梗阻增大而增大，但随大剂量和大流出道梗阻而减小。在没有流出道梗阻的情况下，每次食管收缩都穿过远端到起源部位的整个食管，但在有流出道梗阻的情况下，收缩只穿过部分食管。传播失败的发生率和部位与袖带压力和容积直接相关。食道某一特定部位出现的压力复合体与丸剂从该食道部位通过之间的关系明显受到流出道阻塞的影响。我们认为，食道蠕动可以通过肠容积和流出道阻塞来调节。
We studied the effect of bolus volume and esophageal obstruction on esophageal peristalsis by using synchronized video-fluoroscopic and manometric techniques in cats. A specially designed pressure cuff was surgically implanted around the distal esophagus to control the degrees of outflow obstruction. Secondary esophageal peristalis was evoked by injecting bolus volumes of 3, 6, and 9 ml at cuff pressures of 0, 20, 40, and 60 mmHg. Increases in outflow obstruction reduced the velocity of peristalsis. The amplitude of esophageal contraction increased with increasing outflow obstruction at low bolus volumes but decreased with larger bolus volumes and larger outflow obstruction. In the absence of outflow obstruction, each esophageal contraction traversed the entire esophagus distal to its site of origin, but in the presence of outflow obstruction contractions only traversed part of the esophagus. The incidence and site of failure of propagation was directly related to cuff pressure and bolus volume. The relationship between the onset of manometric pressure complex at a given site in the esophagus to the passage of the bolus from that esophageal site was markedly affected by outflow obstruction. We conclude that esophageal peristalsis can be modulated by the bolus volume and outflow obstruction.