Effect of regional tracer delay on CBF in healthy subjects measured with dynamic susceptibility contrast-enhanced MRI: comparison with 15O-PET.
Effect of regional tracer delay on CBF in healthy subjects measured with dynamic susceptibility contrast-enhanced MRI: comparison with 15O-PET.
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DOI：
10.2463/mrms.4.27
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Kanno, Iwao
中科院分区：
文献类型：
--
作者：
Ibaraki, Masanobu;Shimosegawa, Eku;Kanno, Iwao
目的：基于截断奇异值分解的去卷积方法(SVD去卷积)是动态磁化率增强磁共振成像(DSC-MRI)测量脑血流量(CBF)的一种有前景的方法，但它对示踪剂延迟非常敏感。本研究旨在探讨局部示踪剂延迟对奇异值分解反卷积(SVD-CBF)测定脑血流的影响。将校正延迟前后的SVD-CBF与正电子发射断层扫描(PET-CBF)测量的CBF进行比较，以正电子发射断层扫描(PET-CBF)为定量CBF的金标准。在PET研究中，CBF图像是通过团注H2(15)O和连续动脉采样获得的。在团注Gd基对比剂的DSC-MRI研究中，使用1.5T扫描仪，采用梯度回波平面成像方法，以1-S间隔获得动态血流灌注数据。CBF由SVD去卷积法测定，并对示踪剂延迟进行校正和不校正。结果：白质的示踪延迟明显长于灰质(1.45±0.61vs.0.59±0.35 S，P
PURPOSE: Deconvolution based on truncated singular value decomposition (SVD deconvolution) is a promising method for measuring cerebral blood flow (CBF) with dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI), but it has proved extremely sensitive to tracer delay. The purpose of this study was to investigate the effect of regional tracer delay on CBF determined by SVD deconvolution (SVD-CBF). SVD-CBFs with and without correction for the delay were compared with CBF measured by positron emission tomography (PET-CBF), which is regarded as the gold standard for quantification of CBF.METHODS: Perfusion MRI and PET were performed on seven healthy men. In the PET study, the CBF image was obtained with bolus injection of H2(15)O and continuous arterial sampling. In the DSC-MRI study with bolus injection of Gd-based contrast agent, dynamic perfusion data were obtained with a 1.5T scanner at 1-s intervals by means of gradient-echo echo-planar imaging. CBF was determined by the SVD deconvolution method with and without correction for the tracer delay. Region-of-interest measurements were obtained in the gray matter (cerebral cortex in the middle cerebral artery territory) and white matter (centrum semiovale).RESULTS: Tracer delay was significantly longer in white matter than in gray matter (1.45+/-0.61 s vs. 0.59+/-0.35 s, P