Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.
Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.
复制标题
化合物K和人参皂苷Rh1对大鼠非酒精性脂肪肝的改善作用。
DOI：
10.1038/srep41144
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发表时间：
2017-01-20
影响因子：
4.6
通讯作者：
Ma LQ
中科院分区：
文献类型：
--
作者：
Chen XJ;Liu WJ;Wen ML;Liang H;Wu SM;Zhu YZ;Zhao JY;Dong XQ;Li MG;Bian L;Zou CG;Ma LQ
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, which has no standard treatment available. Panax notoginseng saponines (PNS) have recently been reported to protect liver against hepatocyte injury induced by ethanol or high fat diet (HFD) in rats. Compound K and ginsenoside Rh1 are the main metabolites of PNS. In this study, we evaluated the effects of CK and Rh1 on NAFLD. Rats fed HFD showed significant elevations in liver function markers, lipids, glucose tolerance, and insulin resistance. Treatment with CK or Rh1 either alone or in combination dramatically ameliorated the liver function impairment induced by HFD. Histologically, CK and Rh1 significantly reversed HFD-induced hepatocyte injury and liver fibrosis. In vitro experiments demonstrated that treatment with CK or Rh1 alone or in combination markedly induced cell apoptosis, and inhibited cell proliferation and activation in HSC-T6 cells. Additionally, CK and Rh1, either alone or in combination, also repressed the expression of fibrotic factors TIMP-1, PC-I, and PC-III. Taken together, our results demonstrate that CK and Rh1 have positive effects on NAFLD via the anti-fibrotic and hepatoprotective activity.
